Cellular prion protein (PrPc) is a glycosylphosphatidylinositol-anchored membrane protein that has various physical functions, including protection against apoptotic and oxidative stress, cellular uptake of copper ions, transmembrane signaling, and adhesion to the extracellular matrix. In this study, we ...
Cellular prion protein (PrPc) is a glycosylphosphatidylinositol (GPI) -anchored membrane protein that is highly conserved in mammalian species. PrPc has the characteristics of adhesive molecules and is thought to play a role in cell adhesion and membrane signaling. Here we investigated the possible ...
细胞型朊蛋白(PrPC)能够通过构象转变生成致病型的朊病毒(PrPSc),导致海绵状脑病的发生,但是目前关于PrPC的转变机制还不清楚。PrPC也是重要的信号转导蛋白,引发众多的信号转导事件。Flotillin属于新被命名为SPFH(stomatin/prohibitin/flotillin/HflK/C)的蛋白家族,是重要的脂筏标识性蛋白,它们不仅被动地担当着非胞膜窖脂筏...
The cellular prion protein (PrPC) is a cell surface protein expressed in a variety of different organs and tissues with high expression levels in the central and peripheral nervous systems [1]. It is mainly known for its infamous role in prion diseases, where its misfolding and aggregation cau...
Nonpathogenic cellular prion protein (PrPC) was carried by human plasma EVs and essential for the effects of EVs on PC-12 cells, as EV-induced cell signaling and neurite outgrowth were blocked by the PrPC-specific antibody, POM2. In addition, inhibitors of the N-methyl-d-aspartate (NMDA) ...
Several observations have indicated a possible role of the cellular prion protein (PrPC) in tau toxicity. Initially an interaction between tau and PrPC was proposed, based on neuropathological examination of Gerstmann-Sträussler-Scheinker (GSS) syndrome patients, where abnormally phosphorylated tau de...
Normal cellular prion protein (PrPC) is a conserved mammalian glycoprotein found on the outer plasma membrane leaflet through a glycophosphatidylinositol anchor. Although PrPC is expressed by a wide range of tissues throughout the body, the complete repertoire of its functions has not been fully dete...
Knowledge of the physiological function of cellular prion protein has been acquired from prion diseases such as Creutzfeldt–Jakob disease, as well as
Transition of the prion protein from a structured cellular form (PrP C C ) to the infectious scrapie agent (PrP Sc Sc ) Prion diseases in mammals are caused by a conformational transition of the cellular prion protein from its native conformation (PrPC) to a pathological iso... PK Baral,...
PrPC ProteinsRecombinant ProteinsEnzyme-Linked Immunosorbent AssayBase SequenceDimerizationBoth the purified normal (protease-sensitive) isoform of the prion protein (PrP) (Pergami, P., Jaffe, H., and Safar, J. (1996) 236, 63–73) and recombinant prion protein (PrP) have been found to be in...