Apart from exocrine and endocrine cells, several other cell types mediate specialized physiological functions by secreting tissue-specific, biologically active cargoes via a separate secretory compartment known as LROs. For example, pigment cells, platelets, and cytotoxic lymphocytes secrete melanin, blood...
This phase was also highly enriched for genes involved in N-linked glycosylation, vesicle coating, and unfolded protein response, consistent with these cells actively producing and secreting mucus (Fig. 3a,b). In summary, our in-silico trajectory analysis suggests a developmental lineage of human ...
an indication, that only low numbers of mucus-secreting cells are part of the TMPC models, potentially due to the differentiation of basal cells leading more likely to goblet cell characteristics instead of glandular mucous cells. Since CaLu3 is a cell line derived from an adenocarcinoma of the...
Furthermore, the in vitro analyses could be extended by employing co-cultures of Caco-2 with mucus-secreting cells to assess penetration through this biofilm. 4.3. GET generates endosomal Insulin depots, which benefit chronic delivery and overall transcytosis GET-peptide PLR (and its component ...
Lesuffleur T, Barbat A, Dussaulx E, Zweibaum A (1990) Growth adaptation to methotrexate of HT-29 human colon carcinoma cells is associated with their ability to differentiate into columnar absorptive and mucus-secreting cells. Cancer Res 50(19):6334–6343 CAS PubMed Google Scholar Lomer MCE...
Human ACPA-positive B cells stimulated with citrullinated proteins induce neutrophil migration in vitro by secreting CXCL8, a neutrophil chemotactic factor [26], indicating a role for B cell-neutrophil interactions in RA. In addition, LL-37-DNA complexes derived from systemic lupus erythematosus (...
contin Fig. 1 The structure and homeostatic maintenance of the intestinal epithelium. A, The small intestine is enriched with enterocytes and contains the crypt and villus structures, while the large intestine is enriched with goblet cells and only has the crypt structures. The cell constitution of...
STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation. Int Immunol 2004;16(10):1497–1505. doi:10.1093/intimm/dxh151. (Open in a new ...
(a) HE staining, low power magnification. The photograph demonstrates the diffuse, infiltrating, type of amyloid deposition in biopsy material of patient 2. See how the eosinophilic amyloid material surrounds and embeds the mucus ducts. (b) HE staining. This midpower detail (patient 5) represents...
Serous cells, which also express high levels of CFTR in submucosal glands, are responsible for secreting a mixture of antibacterial proteins (ie lysozyme, lactoferrin, and phosphatases) which may be important in the protec- tion of the airway from diseases.93,94 Hence, given the fact that ...