This phase was also highly enriched for genes involved in N-linked glycosylation, vesicle coating, and unfolded protein response, consistent with these cells actively producing and secreting mucus (Fig. 3a,b). In summary, our in-silico trajectory analysis suggests a developmental lineage of human ...
On the other hand, opening of the epithelial barrier allows for the migration of the inflammatory cells out of the tissue, which, together with the mucus production, cough, ciliary movement and cell death of highly activated epithelial cells, may have a “wash away” effect that reduce the ...
subpopulation of goblet cells (intercrypt goblet cells, icGCs), which are especially located to the surface epithelium between crypts in the colon and contribute to a functional mucus barrier to protect the epithelium from microorganisms (Nystrom et al.,2021). Furthermore, scRNA-seq uncovered an ...
framework may be applied in the context of enteroendocrine cell development within the small intestine to explore ways in which hormone secretion, including that of Glp-1, may be modulated or in the context of goblet cell development to identify agents that may transiently enhance mucus production....
TRXs’ secondary structure is characterized by a β1α1β2α2β3β4β5α4 folding that is common for other proteins of the thiol-dependent antioxidant systems, such as the glutaredoxin, peroxyredoxin, and glutathione (GSH) peroxidase. This folding is divided into different domains: an N-term...
(MCE). MCE are integrated systems formed by multiciliated (MC), mucus-secreting (MS) and mitochondrion-rich (MR) cell populations that are shaped by their microenvironment. Therefore, MCE could be considered as ecosystems at the cellular scale, found in a wide array of contexts from mussel ...
(mm). muscular layer (SMC). parasympathetic ganglion (G), Telocytes (double arrowheads). (H,I,L,M) The esophagus was lined by stratified squamous epithelium (ep) and developed active mucus glands (gl) that exhibited PAS-positive granules. The duct (d) was lined by mucous-secreting cells...
Damage to the Bowman’s glandular cells may impair mucus production, which is necessary for the elimination of odorous particles, and damage to the sustentacular cells can impede the elimination of volatile compounds. This can interrupt the additional supply for the cilia of the ORN and ...
This is a significant stepping stone in the field of tracheal engineering, as there has been controversy in identifying an ideal stem cell that is capable of regenerating ciliated and mucus-secreting epithelium. Second, there is an absence of SMGs within the graft, which equates to an absence ...
depletion of ILCs results in a defective containment of these commensal bacteria and promotes systemic inflammation.36IL-22 secreted by ILC3 has received particular attention in gut homeostasis because of its pleiotropic roles in AMP release, mucus production, intestinal epithelial regeneration and coloniz...