A systemic approach in the evaluation of the various components of the immune system gave an opportunity to identify a number of characteristics of adaptive changes, including the quantitative and functional changes in both innate and adaptive immunity in response to space flight. Among them the ...
As a critical component of innate immunity, the inflammasome is a large multimeric protein complex consisting of the cytosolic sensor NLR, the adapter ASC (apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain) and the effector procaspase-1 [42]. In addition, N...
and ectopic immune stimulation. Under conditions of gut homeostasis, multiple barriers protect the human body from invading microbes; for example, commensal bacteria inhibit the colonization of pathogens.6To protect the first physical barrier separating the gut lumen and the host, both intestinal epithel...
The NFκB and MAPK signaling pathways are critical components of innate immunity that orchestrate appropriate immune responses to control and eradicate pathogens. Their activation results in the induction of proinflammatory mediators, such as TNFα a potent bioactive molecule commonly secreted by recruited...
The workshop was entitled "Resident Cellular Components of the Human Lung: Current Knowledge and Goals for Research on Cell Phenotyping and Function." In this article we will highlight some of the developmental aspects of the lung discussed at the meeting. We will review information about ...
Various cellular innate immune responses protect invertebrates from attack by eukaryotic pathogens. In insects, assessments of the factor(s) causing, or contributing to, pathogen mortality have long considered as toxic components certain molecules associated with enzyme-mediated melanogenesis. In Drosophila ...
Systems biology approaches to dissect mammalian innate immunity Advances in experimental tools have allowed for the systematic identification of components and biological processes as well as quantification of their act... SD Shapira,N Hacohen - 《Current Opinion in Immunology》 被引量: 46发表: 2011...
Insight on cellular and humoral components of innate immunity in Squilla mantis (Crustacea, Stomatopoda) For deeper insights into the function of crustacean haemocytes in immune responses, we studied the morphology and enzyme content of circulating cells of th... C Gallo,F Schiavon,L Ballarin - ...
Type I and III interferons (IFNs) are essential for antiviral immunity and act through two different but complimentary pathways. First, IFNs activate intracellular antimicrobial programs by triggering the upregulation of a broad repertoire of viral restr
Although senescence has not been studied in the cellular components of the choroid plexus, it is known to undergo several age and disease-related structural and functional alterations [131,132]. The choroid plexus produces CSF and forms an interface between blood and CSF. It secretes trophic ...