In this study, we characterise prior knowledge about cellular respiration in undergraduate students enrolled in introductory biology by analysing student-constructed concept maps (N = 182) and interviews (N = 9). Students were instructed to create concept maps from a bank of 20 concepts with the ...
Understanding the combined effect of independent perturbations lies at the core of many fundamental, as well as practical challenges in current biology and medicine. Combination therapies, for example, provide promising new treatment strategies for diseases ranging from cancer to bacterial or viral ...
a, Representative rhythm strip showing termination of EA during CA.b, Electroanatomic maps from a representative CA-treated subject. Top, activation map of EA showing anatomic origin of arrhythmia (early activation, white; late activation, purple). Bottom, activation map overlaid with ablation lesio...
The central dogma of biology tightly links the molecular species DNA, RNA, and protein. Whereas the nucleotide sequence of a gene determines the sequence of its mRNA product, and whereas an mRNA’s sequence determines the amino acid sequence of the resulting polypeptide, there is no trivial rela...
Systems biology data sets (e.g., transcriptomics, phosphoproteomics, metabolomics) could enable comprehensive investigation of the biological impact of these stressors. However, detailed mechanistic networks are needed to determine which specific pathways are activated in response to different stressors and...
The information explosion in biology makes it difficult for researchers to stay up-to-date with current biomedical knowledge and to make sense of the massive amounts of online information. Ontologies are increasingly enabling biomedical researchers to accomplish these tasks [68]. An ontology provides ...
Despite extensively growing knowledge on the molecular biology of ependymoma, effective treatments are still lacking for aggressive subtypes. By applying single-cell RNA sequencing, we comprehensively identify the cellular hierarchy within ependymoma spanning undifferentiated and differentiated tumor cell states ...
This review identifies some key concepts of muscle regeneration, viewed from perspectives of classical and modern research. Early insights noted the patter
nature communications biology articles article Article Open access Published: 30 October 2020 Cellular-resolution mapping uncovers spatial adaptive filtering at the rat cerebellum input stage Stefano Casali, Marialuisa Tognolina, Daniela Gandolfi, Jonathan Mapelli & Egidio D’Angelo Communications Biology...
High-throughput fluorescence microscopy for systems biology. Nature Rev. Mol. Cell Biol. 7, 690–696 (2006). CAS Google Scholar Scheffner, M., Werness, B. A., Huibregtse, J. M., Levine, A. J. & Howley, P. M. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 ...