Cellular arrangement impacts metabolic activity and antibiotic tolerance in Pseudomonas aeruginosa biofilmsdoi:10.1371/journal.pbio.3002205BIOFILMSCLONE cellsANTIBIOTICSPATHOGENIC bacteriaMULTICELLULAR organismsPSEUDOMONAS aeruginosaANATOMYCells must access resources to survive, and the anatomy of mult...
Bacterial infection stimulates autophagy, which is a part of innate immunity used to eliminate intracellular pathogens. Several intracellular bacteria have evolved multipronged strategies to circumvent this conserved system and thereby enhance their chance of intracellular survival. Nonetheless, studies on H....
Chromatins pack inside the nucleus in a spatial arrangement that is specific for a cellular state. Individual chromatins also fold compactly with some sections attached to the nuclear lamina (Fig. II.24). DNA segments within chromatins often associate with nearby regions of the same chromosome cr...
One common assumption is that cellular components guide the spatial architecture and arrangement of multiple species in a biofilm. However, bacteria must contend with mechanical forces generated through contact with surfaces and under fluid flow, whose contributions to colonization patterns are poorly ...
Blocking the import of nutrients essential for cancer cell proliferation represents a therapeutic opportunity, but it is unclear which transporters to target. Here we report a CRISPR interference/activation screening platform to systematically interrogate the contribution of nutrient transporters to support ca...
Arrangement of microtubules and filaments. Planta172: 309–320. Article Google Scholar Tsukada, H., Y. Mochizuki andS. Fujiwara. 1966. The nucleoids of rat liver cell microbodies. J. Cell Biol.28: 449–460. Article PubMed CAS Google Scholar Usuda, N., J.K. Reddy, T. Hashimoto and...
[98]. Small Notch2-expressing cells formed rings around a large Notch2 cell, and these colonies occurred in a repetitive and equally spaced arrangement within the terminal end bud and the trailing duct, where the pattern persisted post-pubertally. Large Notch2+cells appeared with random ...
Previously it has been suggested that monomeric CEACAM1 cluster at the cell surface to help amplify CEACAM1-mediated signaling, potentially through the formation of a lattice-like arrangement of trans-dimers involving CEACAM1 monomers on neighbouring cells[16, 21, 23]. Our simulations support the ...
Properties of “Living” Cells The human body actually contains billions of both prokaryotic and eukaryotic cells which perform metabolic functions, many of them synergistic. Thus, bacteria in the human body are just as essential to the health and survival of a person as are her or his own cel...
Immunometabolism, which is the metabolic reprogramming of anaerobic glycolysis, oxidative phosphorylation, and metabolite synthesis upon immune cell activation, has gained importance as a regulator of the homeostasis, activation, proliferation, and diffe