In cells many K+channels are regulated by their own auxiliary subunits, which profoundly affect the K+channel physiological activities. Since these subunits are specific to each channel and the structural information of them is less well known, they are omitted in this review. Interested readers ca...
Dudek J, Rehling P, van der Laan M (2013) Mitochondrial protein import: common principles and physiological networks. Biochim Biophys Acta 1833:274–285 PubMedCASGoogle Scholar Johnson N, Powis K, High S (2012) Post-translational translocation into the endoplasmic reticulum. Biochim Biophys Acta ...
However, several differential senescence-associated features unique to these individual modalities lead to the question of the nature of physiological aging. The shared and distinctive features of the individual cellular senescence models have been extensively reviewed3–6. An increasing amount of evidence...
The sequential buildup of the 3D in vitro microenvironment enables both proper physiological cell differentiation and at the same time targeted pharmacological manipulation of epithelial cells before the introduction of fibroblasts. Although the key elements of the deteriorated renal microenvironment (i.e....
aggregates are both prevalent features of neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD) and Huntington's disease (HD), a disruption of the UPS machinery and Ub homeostasis might underlie or contribute to pathological senescence in certain physiological ...
Autophagy is a physiological stress response mechanism which is involved in degradation of damaged organelles and misfolded proteins in mammalian cells in both healthy and disease conditions [20], [21], [22], [23]. It plays the second largest role in maintaining proteome stability [17]. The ...
To increase scalability and ease of use, we sought a fluorescence-based system that could be quantified in millions of cells per experiment via automated microscopy. www.aging-us.com 5967 AGING One of the most well-conserved physiological hallmarks of aging is deterioration of nucleocytoplasmic com...
Ubiquitin modification plays significant roles in protein fate determination, signaling transduction, and cellular processes. Over the past 2 decades, the number of studies on ubiquitination has demonstrated explosive growth. E3 ubiquitin ligases are the key enzymes that determine the substrate specificity ...
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In a further aspect, the present invention concerns a method for the identification or classification of a cell status, preferably a physiological or pathological cell state, a differentiation state, a cell cycle state, in a cell, a cell culture, a tissue culture or an animal comprising a cel...