Methods are described for producing enteroendocrine cells that make and secrete insulin in a mammal by blocking the expression or biological activity of one or more forkhead box O (Foxo) proteins or biologically active fragments or variants thereof.Chutima Talchai...
A subset of forkhead box P3 (FOXP3)−CD4+ regulatory T cells that secrete high levels of interleukin-10 (IL-10). TR1 cells were originally described as a subset of naive CD4+ T cells activated ex vivo in the presence of IL-10 or by IL-10-conditioned dendritic cells. TR1 cells ...
VECTORS FOR GENETICALLY ENGINEERED CELLS THAT PRODUCE INSULIN IN RESPONSE TO GLUCOSE not available for EP0707646of corresponding document: WO9500644 The present disclosure relates to the application of genetic engineering to provide artificial beta cells, i.e. cells which can secrete insulin in response...
A potential therapeutic strategy for diabetes is the transplantation of induced-insulin secreting cells. Based on the common embryonic origin of liver and
We have recently demonstrated that pancreatic β-cells synthesize and secrete NGF. We analyzed the effect of endogenous NGF on insulin secretion by incubating islet cells in the presence of an anti-NGF monoclonal antibody for 1 h in different glucose concentrations. Although the basal insulin ...
Pancreatic β-cells secrete insulin primarily in response to increasing blood glucose levels, through the production of metabolic coupling factors (MCF) that promote insulin granule exocytosis. Disturbed glucose and lipid metabolism, including the glycerolipid/free fatty acid (GL/FFA) cycle [[3], [...
Newly generated insulin-secreting cells for use in cell therapy for insulin-deficient diabetes mellitus require properties similar to those of native pancreatic -cells. Pancreatic -cells are highly specialized cells that produce a large amount of insulin, and secrete insulin in a regulated manner in ...
Epidermal growth factor, insulin, and estrogen stimulate development of prolactin-secreting cells in cultures of GH3 cells Pituitary tumor GH3 cells synthesize and secrete both growth hormone (GH) and prolactin (PRL). Morphological and functional changes of GH3 cells induced by... T Kakeya,S Takeuc...
phosphorylation, thereby suppressing E2F activity via Rb. In mild or moderate AKI, senescent cells are effectively cleared by immune cells, thereby promoting adaptive kidney repair. However, severe or persistent AKI leads to the accumulation of senescent cells that secrete the SASP through autocrine ...
The cells secrete into the culture medium hormones such as estrogens, progestins, follicle-stimulating hormone, luteinizing hormone, human chorionic gonadotrophin, thyroxin, glucagon, and insulin, depending on the tissue of origin of individual cell cultures. Contact with an appropriate secretogogue ...