One week after implantation, the morphology of the cells was still fibroblastic but these cells were just about to start to form a cartilage-like matrix. By 6 weeks after implantation, the cells had produced abundant cartilaginous matrix and their morphology became closer to that of aut...
Connective tissue - Migrating Cells, Fibers, Matrix: In addition to the relatively fixed cell types described above, there are free cells that reside in the interstices of loose connective tissue. These vary in their abundance and are free to migrate thr
and CNC cells by modulating the TGFβ, BMP, and FGF signalling pathways; and (iii) provide an appropriate environment for the aggregate to mature into a complex skin organoid unit composed of fully stratified skin with a dermal layer that produces hair follicles, sensory neurons and cartilage. ...
Neural crest cells are highly multipotent stem cells, but it remains unclear how their fate restriction to specific fates occurs. The direct fate restriction model hypothesises that migrating cells maintain full multipotency, whilst progressive fate restriction envisages fully multipotent cells transitioning...
Cartilage extracellular matrix (ECM) plays a crucial role in directing cellular behavior and resisting forces. Owing to the weak self-repairing capability of cartilage, there is a considerable focus on generating scaffold materials that can restore the function and structure of adult skeletal tissues ...
ended with postnatal death. Structural analyses of organogenesis of embryonic lung in these mice showed that YY1 regulated apoptosis and proliferation and is thus essential for lung branching [62]. Moreover, YY1 ablation diminished the density and diameter of the ring cartilage distributed along the ...
Skin stem cells form, for example, keratinocytes, which form a protective layer of skin. The proliferation time of somatic stem cells is longer than that of ESCs. It is possible to reprogram adult stem cells back to their pluripotent state. This can be performed by transferring the adult nucl...
Abstract: Somites are blocks of embryonic mesoderm tissue that give rise to skeletal muscle, cartilage, and other connective tissues. The development of different tissues within the somite is influenced by adjacent structures, in particular, the neural tube and notochord. Results of experiments performe...
Mesenchymal stem cells (MSC) derived from adult BM or fetal liver form several mesenchymal tissues after appropriate stimulation. Reports indicate that MSC... B Le,K. - 《Cytotherapy》 被引量: 1723发表: 2003年 Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult...
NCCs are transient cell populations that arise from the neural plate border (NPB). They migrate from their dorsal origin to the ventral craniofacial primordium and contribute to the cartilage, bones, and connective tissues. The facial primordium is divided into three parts, the frontonasal ...