the researchers started with a human embryonic stem cell line, which they chemically nudged to become cells that form what' s known as the primitive streak on the hollow ball of cells of the early embryo; and knowing that often the cells progressed down the developmental path through a series...
Cartilage tissue and implants comprising tissue are produced in vitro starting from cells having the ability to form an extracellular cartilage matrix. Such cells are brought into a cell space ( 1 ) and are left in this cell space for producing an extracellular cartilage matrix. The cells are ...
Connective tissue - Migrating Cells, Fibers, Matrix: In addition to the relatively fixed cell types described above, there are free cells that reside in the interstices of loose connective tissue. These vary in their abundance and are free to migrate thr
A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury The growth plate cartilage supports long bone growth. Here the authors identify FoxA2+ long term stem cells in the growth plate that are stratified with short term PTHrP+ cells, participate ...
Stromal cells, or mesenchymal stem cells, are adherent clonogenic cells that can form colonies. They are mainly isolated from bone marrow but can also be found in umbilical cord blood, adipose tissues and amniotic fluids. These stem cells are easy to culture in vitro, and can differentiate into...
Cells of non-lymphoid origin that form the framework of each organ. By expressing various molecules, these cells can support the adhesion, proliferation and survival of distinct cell subsets. Mesenchymal tissues These are embryonic tissues of mesodermal origin, consisting of loosely packed, unspecialized...
This review focuses on the various candidate genes that encode signalling molecules and transcription factors that are specific for the enhancement of the chondrogenic phenotype and also how epigenetic regulators of chondrogenesis in the form of microRNA may also play an important role. 展开 ...
Acute kidney injury (AKI) is a prevalent and life-threatening clinical condition characterized by a rapid decline in kidney function, with a high incidence and mortality rate [1]. However, the prognosis for surviving patients with AKI is far from optimistic. Research has shown that 30% to 70...
Short term systemic expression of the reprogramming factors Oct-3/4, Sox2, Klf4, c-Myc (OSKM) rejuvenates aging cells and promotes tissue regeneration. Here the authors show that myofiber-specific expression of OSKM accelerates muscle regeneration by reducing secretion of muscle stem cell quiescence...
Considering that placental MSCs is an allogenic source, it has advantages such as being painless, easily lyophilized (MSC-lyophilisate), accessible and free of charge compared to bone marrow. Other factors that make MSC-lyophilisate preferable including anti-inflammatory factors, chemokines, cytokines...