AM internalization can be seen as puncta located in the cytoplasm. Control conditions at 4 °C did not yield a measurable pHrodo Red Avidin signal (data not shown). Three independent experiments were performed. E Representative example of flow-cytometry-based indirect internalization assay of ...
For each transcript in each sample in this study, single-cell transcriptome-wide coverage was quantified by counting the number of unique barcode/UMI pairs seen across the whole transcript. Then, for each position along the transcript, the number of unique pairs was divided by this total. This...
T cells are functionally not impaired in AML: increased PD-1 expression is only seen at time of relapse and correlates with a shift towards the memory T cell compartment. J Hematol Oncol 2015;8:93.Schnorfeil FM, Lichtenegger FS, Emmerig K, Schlueter M, Neitz JS, Draenert R, et al...
Hence, NK cells can be rarely seen in metastatic melanoma and are mainly TIGIT−CD226− which are deprived of cytotoxicity toward MHC-I-defient malignant cells [153]. Interestingly, proved by convincing genetically engineered models, it is the absence of NK cells but not CD8+ T cells that...
The most common mutation seen in the donors and the cancer patients studied is in a gene associated with heart disease. Healthy people with mutations in this gene are at higher risk of heart attack due to plaque buildup in the arteries. ...
Early evidence for CSCs was first seen in hematological malignancies. In 1994, Lapidot et al. identified a subpopulation of tumor-initiating cells in acute myelogenous leukemia (AML) [7]. The identification of these leukemic initiating cells was based on differential expression of cell surface ...
In other non-HSCT settings, BOOP has been seen in association with infection, drugs, radiation therapy, and a number of connective tissue disorders [90]. It has also been shown that the 2-year cumulative incidence of late-onset non-infectious pulmonary complications (LONIPC, including BO and ...
a treatment resistant tumor. Evidence for this can be seen in chemotherapy resistant tumors which have an acquired increased expression of the multi-drug resistance genes (e.g., MDR1), which encode for drug efflux pumps. These pumps are highly expressed in CICs and are thought to be a ...
It is seen, for example, when cytostatic drugs, such as hormonal receptor blockers, are used to treat hormone-sensitive cancers (Saad and Fizazi, 2015). Stable disease could be related to tumors in which cancer cell proliferation is very slow or is balanced by cancer cell death. Thus, it...
Ethanol-induced hepatic lipophagy plays an important cytoprotective role against liver injury, but its mechanism is not fully determined. In the present study, ethanol-induced lipophagy was studied in an immortalized mouse hepatocyte line, AML12. We foun