Immunology Antigen presenting cells in the retina UNIVERSITY OF MINNESOTA Dale S. Gregerson LehmannUteThe presence and activity of dendritic cells (DC) in retina is controversial. This is in part due to the lim
His research team discovered that cells that lie dormant in the retina (glial cells) can be induced to transform into cells sharing some properties withcone photoreceptors, which allow people to do things like perceive colors, read and drive. Inherited retinal degenerations are caused by the loss...
" said Wong, "we might be able to miss the worst of the inflammation, but still come back into balance at a later point in time. We could hit pause on the immune system in the retina in a directed way."
(1921). Histogenesis of the visual cells in Amblystoma. J. Comp. Neurol. 33 :493–508.Detwiler, S. R. , and Laurens, H. 1921 Studies on the retina. Histogenesis of the visual cells in Amblystoma . Jour. Comp. Neur. , vol. 33 , no. 5 , pp. 493 – 508 ....
In the present study, we demonstrate for the first time that a transient increase in H2O2 occurs in retina-derived 661W cells when they are subjected to the stress of serum withdrawal. We propose that this oxidant burst, which is due at least in part to Nox2 activity, has two principle ...
"Inflammation of the eye, known as uveitis, is very common following infection with Ebola and we know the cells within the iris, at the front of the eye, as well as the retina has the capacity to play a major role in uveitis and act as hosts for microorganisms," Justine Smith, researc...
but little is known about this mechanism in the retina. The present study demonstrates for the first time that hydrogen peroxide (H2O2) is generated rapidly and acts as a pro-survival signal in response to a variety of apoptotic stimuli in retina-derived 661W cells and in the retinal ganglion...
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pA monoclonal antibody (MAb-1E7), generated against bovine retinal homogenate, labeled the outer and inner segment layers of the vertebrate retina. Immuno-electron microscopic observation clearly demonstrated that antigen(s) bound by MAb-1E7 was localized in the cell membrane of the outer segment ...
eGFP expression was strongest in the retina, optic nerves and brain when driven by the sCAG and SYN promoters. CBA, CMV, and PGK had moderate expression by comparison. The SYN promoter had almost exclusive transgene expression in RGCs. The PGK promoter had predominant expression in both RGCs ...