Programmed death ligand 1 (PD-L1) plays a key role in glioblastoma multiforme (GBM) immunosuppression, vitality, proliferation, and migration, and is therefore a promising target for treating GBM. CRISPR/Cas9-mediated genomic editing can delete both cell surface and intracellular PD-L1. This system...
An uncycled preconditioned electrode for a non-aqueous lithium electrochemical cell including a lithium metal oxide having the formula Li (2+2x)/(2+x) M′ 2x/(2+x) M (2−2x)/(2+x) O 2−δ , in which 0≦x<1 and δ is less than 0.2, an... MM Thackeray,CS Johnson,K Amin...
Large-area F-PSCs could be significant for accelerating the commercialization of F-PSCs. Significant achievement has been obtained in producing large-scale F-PSCs currently; however, issues are hindering to achieve commercialization and applications of F-PSCs. For example, it is difficult to manuf...
14and Stunted (sun).15In response to these satiety signals, IPCs can be activated and exert robust effects on flies’ feeding behavior and metabolism.4Nevertheless, it remains unclear whether IPCs are the universal satiety sensor in the fly brain or merely function as a ...
Over the past 20 years, and particularly in the last decade, significant developmental milestones have driven basic, translational, and clinical advances i
Axin2-expressing cells are responsible for epithelial regeneration in vivo and for endometrial organoid development in vitro. Ablation of Axin2+ cells severely impairs endometrial homeostasis and compromises its regeneration. More important, upon oncogenic transformation, these cells can lead to endometrial...
To evaluate the advantages and challenges of combining proteomic and functional genomic screening platforms for deducing functional adaptations associated with enteroendocrine cells, we have performed pilot parallel large-scale analyses of gene and protein expression in mitotically active asynchronous cultures ...
In addition, we introduce a series parallel partition method of branches of a graph, so that the derivation of a general formula for the number of trees in an iterative graph is simplified. Then for individual iterative graphs, we show concrete examples and the results of the determination ...
In addition, dyngen can simulate a large variety of dynamic processes (e.g. cyclic, branching, disconnected) as well as a broad range of experimental conditions (e.g. batch effects and time-series, perturbation and single-cell knockdown experiments). For these reasons, dyngen can cater to a...
To reach record performance, metal-halide PSCs must effectively control light. To improve the Jscfor high energy yields, criteria on materials, and photonic engineering are defined in this article. In order to further improve performance in the case of all-perovskite, two-terminal parallel cells,...