Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is known to contain an active-site cysteine residue undergoing oxidation in response to hydrogen peroxide, leading to rapid inactivation of the enzyme. Here we show that human and mouse cells expressing a GAPDH mutant lacking this redox switch retain ...
Generally, the cellular size is the smallest immediately after cell division (at birth); the daughter cells grow during the cell cycle and become the largest just before the next division, in which cells maintain their original cell size. Cell size homeostasis has been mainly studied in yeasts ...
a long cell cycle length of about 30h is due to an extended G2 phase (18h) in comparison to G1 (8h) and S (4h) [12•]. If cells did not grow in G2, but in G1, then the average size of non-dividing cells, most of which are in G2, should be closer to tha...
Schwann cells are the most prevalent cell type in peripheral nerves, comprising 90% of the endoneurial space (Campana, 2007). Schwann cells are plastic; they become activated as evidenced by dedifferentiating, proliferating, and migrating in response to peripheral insults such as inflammation or ner...
Pancreatic β cells differentiated from stem cells provide promise for cell replacement therapy of diabetes. Human pluripotent stem cells could be differentiated into definitive endoderm, followed by pancreatic progenitors, and then subjected to endocrin
Here, we will refer to all these cell-like systems shortly as synthetic cells (SCs), but most of the discussion will be focused on SCs built from biomolecules as DNA, RNA, ribosomes, enzymes, etc. encapsulated within liposomes. The resulting SCs will function by enzyme catalysis and/or by...
In recent years, stem cell therapy has become a very promising and advanced scientific research topic. The development of treatment methods has evoked great expectations. This paper is a review focused on the discovery of different stem cells and the pot
-G1: Gap 1 phase in which the cell grows and makes proteins. The cell spends most of its time in this phase -S: Synthesis phase in which DNA replication occurs, doubling the number of chromosomes (chromatin duplicates) -G2: Gap 2 phase in which there is more growth and protein synthes...
the 2D materials described as cohesive energy is inversely proportional to the bond length. Among the 2D materials, high-symmetry graphene shows the shortest bond length, making it the most stable 2D material known to date. The electronic bands near the six corners of the 2D hexagonal Brillouin...
The most prevalent chromatin-based scATAC-seq clusters in terms of cell number (0, 1, and 2) were persistent (Fig.1e) and defined by fewer than 20 unique DARs, suggesting that 74% of the cells share an overall similar chromatin-accessibility profile during the development of ENZ resistance...