Genes close together Not assorted independently No 1:1:1:1 ratio Nonrecombinants Alleles that are present in the same combination as in the parent Recombinants Results from a cross over, exchange of parts of homologous chromosomes Frequency of recombination ...
The recent emergence of human induced pluripotent stem cell (hiPSC)-based models has provided the field with a highly innovative approach to generate, study, and manipulate living neural tissue derived from patients, making possible the exploration of fundamental roles of genes and early-life stress...
Specific TaqMan probes could not be designed (short and/or G-rich regions within the rearranged TCR genes). Figure 6. Infused HIV-specific CD8+ T-cell clones survey the rectal mucosa. (A-B) Fluorescence images of fresh rectal tissue sections (30 μm) from patient 7707 (A) and 7709 (B...
Osteogenesis imperfecta (OI) is a disease caused by mutations in different genes resulting in mild, severe, or lethal forms. With no cure, researchers have investigated the use of cell therapy to correct the underlying molecular defects of OI. Mesenchymal stem cells (MSCs) are of particular inte...
Genes associated with the immunological synapse also are upregulated, suggesting that these features promote stronger activation of T cell receptor (TCR) and increased TCR-mediated target cell death. We believe that our work will contribute to feasible “off-the-shelf” T cell therapy with robust ...
In humans, major HLA-I-specific inhibitory receptors are represented by the C-type lectin CD94/NKG2A dimer that recognizes the non-classical HLA-E alleles, and the Killer Ig-like Receptors (KIR). The CD94/NKG2A encoding genes are located in the NK Receptor complex on chromosome 12, while...
Previous expression study using quantitative proteomics has shown that immune-mediated pathway may not be the main mechanism inducing alopecia areata (AA). Nevertheless, functional impact of such expression data set remained unknown and unexplored. This
These cells share with Th17 cells the expression of the orphan nuclear receptor RORγt, which is both necessary and sufficient for expression of the genes that currently define the Th17 program (Ivanov et al., 2006). In addition to RORγt, multiple other transcription factors (TFs) have ...