4a–c) at 0 h post isolation. Importantly, MuSC Cluster 3 is completely lost in aged mice (Fig. 3a,b), likely due to reduced propensity for early activation and delayed entry into cell cycle of aged MuSCs compared to young38 (Supplementary Fig. 4)....
known as myofibers, which are formed by the fusion of myogenic progenitor cells. Despite the post-mitotic nature of its myofibers, skeletal muscle has a robust regenerative capacity in response to injury. This relies on resident muscle stem cells (...
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Particularly, as a key regulator of the cell cycle and to provide a rationale for the experimental observation that the cell size seems to play an important role in establishing an increased cell number, before it can be incorporated into cell lines that are used for the production of ...
1A). Compared with HepaRG that was induced by 2% DMSO, the QPCR analysis of HepaRG cultured by HMM showed a rapid increase in the expression of multiple liver function genes, such as drug metabolism enzyme CYP3A4, plasma protein α-antitrypsin (AAT), albumin (ALB), urea cycle key enzyme...
order of signaling events in G1. Finally, we show that this signaling inversion leads to a point of no return that is marked by Rb inactivation instead of APC/CCDH1inactivation. Thus, to start the cell cycle, cells can first activate CDKs via upregulation of D or E-class cyclins, then...
In order to clarify which of the two IF1 binding sites might be involved in the desensitization of the PTP between (1) the canonical site in the F1 sector or (2) the new one on the OSCP subunit, mouse embryonic fibroblasts (MEFs) were generated overexpressing the IF1 mutant Y33R (IF1...
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