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Research Open access Published: 12 January 2024 Single-cell sequencing reveals the heterogeneity of B cells and tertiary lymphoid structures in muscle-invasive bladder cancer Hao Yuan, Xingning Mao, Yunkun Yan, Rong Huang, Qingyun Zhang, Yanyu Zeng, Mengying Bao, Yan Dai, Bo Fang,...
Organization of the human intestine at single-cell resolution Article Open access 19 July 2023 Single-cell integration reveals metaplasia in inflammatory gut diseases Article Open access 20 November 2024 A Roadmap for the Human Gut Cell Atlas Article 31 May 2023 Main...
At the transcriptomic level, the presence of increased numbers of PDX1HIGH and MAFAHIGHβ-cells leads to dysregulation of gene pathways involved in metabolic processes. Using a chemogenetic disruption strategy, differences in PDX1 and MAFA expression are shown to depend on islet Ca2+ signaling ...
As well as the normal Scs, also CSCs are thought to reside at the top of the lineage hierarchy and give rise to differentiated cells, which themselves have no potential for self-renewal, and therefore do not contribute significantly to tumor growth. Due to their long life, SCs remain in a...
Our work revealed that mesenchymal cells showed specific transcriptome profiles to differentiate tooth types. We found significant differences in markers, regulons, and signaling pathways between the molar and incisor mesenchyme at E12.5, which is considered a shifting stage of odontogenic potential. In...
Methods PC3 cells were treated with HVJ-E at various multiplicity of infection (MOI), and the generated reactive oxygen species (ROS), cell viability, apoptosis, and autophagy were detected, respectively. Next, the role of ROS played in the regulation of HVJ-E-induced apoptosis and autuphagy ...
CLAHE [61] is used on the entire dataset to improve the contrast of the dataset images and to make cell bodies more prominent. However, CLAHE can only work on one color channel at a time. For this purpose, this research uses a different technique. First, the image is split into its 3...
TRAIL (Sino Biological Inc. Beijing, China) was added to the cells at 50 ng/mL to achieve 80% cytotoxicity. When the cells returned 50% confluence, they were treated with 60 ng/mL TRAIL. After several rounds of TRAIL administration, the dose was increased to 100 ng/mL. The cells ...
Article Open access Published: 24 January 2024 Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity Isaac Dean, Colin Y. C. Lee, Zewen K. Tuong, Zhi Li, Christopher A. Tibbitt, Claire Willis, Fabrina Gaspal, Bethany C. Kennedy, ...