A high-performance register file is implemented in a multi- block structure consisting of sub-arrays and associated multiplexing circuits. For a given port, the outputs of all multiplexer circuits are dotted together to form a single global output. The multiplexer circuits may be completely external...
Instead, the converging evidence supports the existence of a continuum of cell properties and a uniform organization principle of cortical circuits. 2. Results 2.1. The rectification model We assume that the time-modulation of the membrane voltage in cortical neurons in response to a drifting ...
shared progenitors for melanocytes and glia have been proposed25,26, and whilst in mouse migrating NC cells retain multipotency (defined there as at least bipotency)27, neural derivatives appear to originate via a PFR mechanism involving bipotent neuroglial progenitors28....
The hippocampus is a major brain centre for information processing, where subcortical neuromodulatory circuits interface with intrinsic learning circuits to assign salience to sensory information relevant to behavioural state. Glutamatergic principal cells (PCs) of the dentate gyrus (DG), CA3 and CA1 re...
The immune system is a sophisticated network of different cell types performing complex biocomputation at single-cell and consortium levels. The ability to reprogram such an interconnected multicellular system holds enormous promise in treating various d
Ultrasound has been used to non-invasively manipulate neuronal functions in humans and other animals. However, this approach is limited as it has been challenging to target specific cells within the brain or body. Here, we identify human Transient Recept
Stem cells are a unique class of cells that can be distinguished by their distinct capabilities to differentiate into specialized lineages for the self-repair of various tissues and organs in the human body [6]. As such, controlling stem cell fate has become one of the most important topics ...
The UW researchers built their circuits, the largest ever published to date in eurkaryotic cells, using DNA instead of silicon and solder, and inside yeast cells instead of at an electronics workbench. Eurkaryotic cells, like human cells, contain a nucleus and other structures that enable compl...
This chapter can be seen as a continuation of the precedent one in which the relationship between pyramidal neurons acquires a categorical treatment. Here we extend this view to sketch a theory of declarative memory, building on the results described on the previous chapters. The original and inno...
Energy and oxygen tune NHE activity and as in the previous model of tumor cell metabolism and growth6,7,8, here we take into account these regulatory circuits by means of the two variables SensATP and SensO2 that assume real values in the interval [0, 1]. Experimental observations indicate...