B cells contribute to RA development by producing antibodies specific for self-proteins, and/or altered self-proteins, such as collagen type II (CII), Fc portion of IgG (rheumatoid factor) and citrullinated protein antigens18. To corroborate the importance of antibodies in the pathogenesis of CIA...
2c and Extended Data Fig. 2b,c). We also detected upregulation of Diap1-GFP in single epidermal cells next to the bristles of the thoracic epidermis (Extended Data Fig. 2d,e), suggesting that F-Cells associate with differentiating tactile bristles in different body parts. Fig. 2: F-Cell...
(4) large-scale expansion of Treg cells, by performing all in-process controls and release tests on the finished product; (5) functional testing of Treg cells (in vitro suppression test); and (6) cryopreservation and thawing, and subsequent evaluation of the expansion ability of the thawed ...
The main steps of the validation process are shown schematically in Fig.1, while details of the operations conducted are described in the “Methods” section. Briefly, we performed (1) starting material QCs, including donor validation, leukapheresis collection, and temperature-controlled transportation;...
an SC is capable of long-term self-renewal and multilineage differentiation [1]. SCs residing in our body are responsible for the maintenance of tissue homeostasis; however, identifying definite markers for SCs in vivo remains the biggest challenge in the field of SC research. Recent advances in...
The second and all subsequent even-numbered containers included 3 U of plasma, 1 dose of platelets (a pool of 6 U on average), and 6 U of RBCs, which were transfused in the following order: platelets first, then alternating 2 U of RBCs and 1 unit of plasma. Patients with multiple ...
From 18 h to 30 h this value remained constant (paired t-test). Full size image Systemic and localized inflammatory responses to S. aureus intra-mammary infection As an indicator of a systemic response to S. aureus infection, rectal temperatures were monitored throughout the study. Body ...
Stem cells also act as internal repair systems of the body. The replenishment and formation of new cells are unlimited as long as an organism is alive. Stem cell activity depends on the organ in which they are in; for example, in bone marrow, their division is constant, although in organs...
Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders, including COVID-19. However, there are still no effective drugs to treat lung injury and fibrosis. In this study, we report the generation of clinical-gr
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