Here, only paucity of T cells was discovered in the parenchyma and stroma of gastric cancer tissues, which can be characterized as an immune-desert phenotype. However, we found a thin cluster rich in Plasma B cell, Follicular B cell, and Th2-like CD4 + T cell at the interface of ...
The reduction in white bloodcellcounts lowers resistance to disease. 白细胞总数的减少,会降低对疾病的抵抗力. 《简明英汉词典》 The fission of thecellcould be inhibited with certain chemicals. 细胞的裂变可以通过某些化学药品加以抑制. 《简明英汉词典》 ...
From the ancient Romans, through the Middle Ages, to the late of the nineteenth century, the Aristotelian doctrine of spontaneous generation was one of the most basic laws. Even the invention of the microscope and investigations of Leeuwenhoek and Hook d
Current treatment strategies for cancer, especially advanced cancer, are limited and unsatisfactory. One of the most substantial advances in cancer therapy, in the last decades, was the discovery of a new layer of immunotherapy approach, immune checkpoint inhibitors (ICIs), which can specifically acti...
It was discovered that graphene can serve as a platform with increased adhesion for both growth factors and differentiation chemicals. It was also discovered that π-π binding was responsible for increased adhesion and played a crucial role in inducing hMSC differentiation [150]. Therapeutic ...
In 2013, it was named “Nature Methods” as the annual technology [2]. However, early single-cell sequencing limited its widespread use due to its high cost. But as the research progressed, many new single-cell sequencing methods were developed that reduced the cost threshold for single-cell...
Global regulators engineering was also employed to attenuate endogenous oxidative stress emerging from the oxidative folding process. Hap1 is a single TF managing aerobic metabolism in S. cerevisiae. It is responsible for sensing the oxygen levels via the heme signaling pathway, and activation of the...
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or even a variety of diseases in the body. In the past several decades, apoptosis has traditionally been considered the only form of programmed cell death, a gene-regulated active cell death. However, necrosis was considered an accidental form of cell death, an uncontrolled passive cell death ...
Finally, we revealed the dysregulated cell-cell communications in keratoconus, and found that only few ligand-receptor interactions were gained but a large fraction of interactional pairs was erased in keratoconus, especially for those related to protease inhibition and anti-inflammatory process. Taken ...