Here, only paucity of T cells was discovered in the parenchyma and stroma of gastric cancer tissues, which can be characterized as an immune-desert phenotype. However, we found a thin cluster rich in Plasma B cell, Follicular B cell, and Th2-like CD4 + T cell at the interface of ...
In the early 1600s (about 1610), the great Galileo Galilei (1564–1642) constructed several simple microscopes and telescopes, which he called as “occhialino.” The term “microscope” was used for the first time in 1625 by the Italian physician Giovanni Faber [1]. The first publication, ...
remains extremely rare in the Precambrian rock record. We here report the first occurrence of exceptional cellular preservation by the rare earth element (REE) phosphates monazite and xenotime. This occurs in ~1 billion-year-old lake sediments where REEs were likely concentrated by local erosion...
Metastatic pulmonary nodules discovered 6 years after superficial parotidectomy for an acinic cell carcinoma in a 61-year-old man were studied by light and electron microscopy. The lesions were composed of clear cells and darker, gland-forming cells with granular cytoplasm, which by electron ...
The date an article was first made available online will be carried over. Please be aware that, although articles in press do not have all bibliographic details available yet, they can already be cited using the year of online publication and the DOI, as follows: author(s), article title,...
It was discovered that graphene can serve as a platform with increased adhesion for both growth factors and differentiation chemicals. It was also discovered that π-π binding was responsible for increased adhesion and played a crucial role in inducing hMSC differentiation [150]. Therapeutic ...
The date an article was first made available online will be carried over. Please be aware that, although articles in press do not have all bibliographic details available yet, they can already be cited using the year of online publication and the DOI, as follows: author(s), article title,...
According to several reports, G protein-coupled receptor class-C group-5 member-D (GPRC5D) could be an essential target (Fig.2). Hair follicles seem to be the only normal tissue in which GPRC5D expression has been discovered outside of cancerous bone marrow plasma cells [157]. Researchers...
Second, the Hippo pathway, which was discovered in genetic screens of theDrosophilaeye [109], has previously been implicated in the regulation of tissue growth and apoptosis. Research investigating the roles of the Hippo pathway in intestinal regeneration has clearly progressed over the past few yea...
In 2013, it was named “Nature Methods” as the annual technology [2]. However, early single-cell sequencing limited its widespread use due to its high cost. But as the research progressed, many new single-cell sequencing methods were developed that reduced the cost threshold for single-cell...