This paper presents progress in the automation of cell and tissue systems and attempts toward the in situ feedback control of organs-on-a-chip. Our study aims to achieve feedback control of a cell and tissue system by a personal computer (PC), whereas mo
There’s a lot of science discussing the association between mast cells and nerves in most tissues, including studies that suggest the mast cells are constantly providing information to the nervous system. Mast cells are also widely distributed in both connective tissue and mucosal surfaces, and int...
Here, we developed a blood test to broadly quantify cell-, tissue-, and organ-specific injury due to COVID-19. Methods Our test leverages genome-wide methylation profiling of circulating cell-free DNA in plasma. We assessed the utility of this test to identify subjects with severe disease in...
However, our integrated dataset may also be used for future tissue-targeted and organ-wide studies on the age-associated changes in the human heart. The next step for clinical translation is to disentangle the gene networks that regulate adult and fetal epicardial states. In doing so, we might...
which stimulate vasculogenesis and the proliferation and maturation of cells within the myocardial tissue5. These developmental abilities also translate into a regenerative role. Adult zebrafish hearts are capable of regeneration, and developmental epicardial genes become highly expressed at the infarcted regi...
mIF confirmed their presence in HCC tissue microarray (TMA), and also illustrated the exclusion expression of these three markers in HCC tumor cells, aligning with the findings from the scRNA-HCC cohort (Fig. 1I). Additionally, we also validated the classification in spatial transcriptome (ST) ...
The tissue processing pipeline for examining single cell using scRNA-seq is shown in Fig. 1B. The scRNA-seq data were merged, normalized, batch-effect corrected, and clustered to identify the cell types. After quality control filtering, an average of 6633 unique transcripts per cell were ...
tissues, which may be due to the greater number of tumor cells in tissue samples. However, more high-frequency gene mutations were found in CTCs. Fig. 7 Detection of gene mutation and its clinical significance.AFlow chart of gene detection for HCC patients.BGene mutations in primary tissues,...
Single-cell transcriptome atlas of lamprey exploring Natterin- induced white adipose tissue browning Yue Pang Yating Qin Guangyi Fan Nature Communications(2025) aKNNO: single-cell and spatial transcriptomics clustering with an optimized adaptive k-nearest neighbor graph ...
Single-cell and single-nucleus RNA-sequencing (sxRNA-seq) is increasingly being used to characterise the transcriptomic state of cell types at homeostasis, during development and in disease. However, this is a challenging task, as biological effects can