system so that the acid balance suits the cells in culture.Tissue culture mediainclude neutralred as a pH indicator. This is why healthy tissue cultures have a pink colour, whereas infected tissue cultures turn bright yellow. It is important to maintain tissue cultures in the dark since the ...
Organism-level systems biology by next-generation genetics and whole-organ cell profilingdoi:10.1016/j.ibror.2019.07.115Hiroki UedaIBRO Reports
tissue types that subsequently develop. This ability to repopulate mouse embryos is the key defining feature of embryonic stem cells, and because of it they are considered to bepluripotent—that is, able to give rise to any cell type of the adult organism. If the embryonic stem cells are ...
The sequestration of actin released into the extracellular environment is essential to avoid organ damage and to restore DNase activity. However, the relationship between chromatin, actin, DNases and the actin-scavenger system is complex due to their dynamic interactions. The extracellular actin-scaveng...
2c). A potential reason for the difference in classification performance between different organ systems lies in the number of observed cell types per organ system - the F1-scores have a correlation of −0.55 (p-value: 0.035) with the number of observed cell types per organ system. The ...
The combination of single-cell analysis, CRISPR/Cas9 gene editing, three-dimensional cell (3D cell) analysis and artificial intelligence (AI) enables in-depth exploration of tissue heterogeneity in atherosclerosis plaques, blood, liver, and the intestinal tract. This approach can guide early diagnosis...
Pathway Analysis is statistically linking observations on the molecular level to biological processes or pathways on the systems(i.e., organism, organ, tissue, cell) level. Traditionally, pathway analysis methods regard pathways as collections of single genes and treat all genes in a pathway as equ...
The third important factor in organ or tissue printing process is laser‐assisted bioprinting (LAB). The LAB device consists of a pulsed laser beam, a focusing system, a “ribbon” that provides transport of material, and substrates for cell‐containing material. The materials used in ...
Stromal progenitors are found in many different tissues, where they play an important role in the maintenance of tissue homeostasis owing to their ability to differentiate into parenchymal cells. These progenitor cells are differentially pre-programmed b
employ strict asymmetric cell division as seen in some invertebrate systems or they also undergo symmetric division. Given that many mammalian tissues have two distinct stem cell-populations in the same tissue, does this also apply to the muscle system to ensure quick response to the tissue damage...