Pasteur's theory was rejected in its entirety by Virchow who was convinced that the diseased tissue was caused by changes within healthy cells, but not from invasion of other organisms [49]. Virchow tried to understand the nature and origin of cancer, and some of his theories were correct; ...
was involved in the discussion of content and at all stages of revision. Corresponding author Correspondence to Hans Clevers. Ethics declarations Competing interests H.C. is the inventor on several patents related to organoid technology; his full disclosure is given at https://www.uu.nl/staff/...
000 cells reprogramming from MEFs to iEPs49(Fig.5dand Supplementary Note2). It took CellRank about 33 s to compute macrostates from this large dataset (Supplementary Table1). For fate probabilities, the (generalized) linear model STEMNET was fastest as expected, taking only 1 min, while...
inhibitors; TNT inhibitors reduced mitochondrial transfer to multiple myeloma cell lines by up to 46.19%, whereas there was no significant reduction observed with endocytosis inhibitors [53]. Moreover, there was no mitochondrial transfer from BMSC to malignant plasma cells when multiple myelomas were ...
According to the idea of the differentiation theory, it implies that both errors in the genetic program and DNA replication are at least moderately affected by exogenous factors. Age-related alterations of the lymphohematopoietic system, particularly of its lymphoid part, are well reported. However,...
According to one theory, stem cells from the bone marrow go into tissue and become cells of that tissue [13]. Aging is a balance between entropy (aging or slow breaking down of tissue) and rebuilding (stem cells). If the power of entropy is bigger than the rebuilding abilities of stem ...
We formulated the prediction of cell-type-specific genes as a set of six binary-class classification tasks. The prediction was performed by using ℓ2-norm regularized logistic regression [45]. We also employed the ℓ1-norm regularized logistic regression [39] and stability selection for image...
Chinese scientists that followed their education abroad, including Beike Biotech founder Xiang Hu, were trained in ‘Western’ laboratories and became well versed in scientific theory. When returning home, however, they landed in a very different institutional and regulatory environment, whereby the ...
These are based on the theory that specific DNA-PAINT localizations are indicated by repetitive transient binding events that are evenly distributed over the acquisition time, leading to a mean frame of around half the number of total frames acquired. Unspecific binding is indicated by a ...
n = 9 biologically independent samples from a total of three separate experiments, each experiment was normalized to the control mean fluorescence intensity (MFI). e, f P-value was calculated using one-way ANOVA followed by Tukey’s multiple comparisons test. Error bars represent ± ...