Cell type assignment is a major challenge for all types of high throughput single cell data. In many cases such assignment requires the repeated manual use of external and complementary data sources. To improve the ability to uniformly assign cell types
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NF-κB transcription factors are critical regulators of innate and adaptive immunity and major mediators of inflammatory signaling. The NF-κB signaling is dysregulated in a significant number of cancers and drives malignant transformation through mainte
Introduction Cells are the basic units of the life activities of living organisms. Researches based on single-cell analysis are the foundation of bioscience. The differences between cells are always hidden by cell groups [1], while single-cell analysis can provide more precise and detailed ...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy
The insertion of pyrrolysine, or any other non-canonical amino acid, in response to an in-frame amber codon is termed ‘stop codon suppression’ (SCS). The MmPylRS/MmtRNACUAPyl pair is orthogonal in E. coli and other host organisms, i.e. MmPylRS does not charge any host tRNAs with ...
Daqu is the most important fermentation starter for Chinese liquor, with large number of microbes and enzymes being openly enriched in the Daqu system over thousands of years. However, only a few enzymes have been analyzed with crude protein for total li
The present invention relates to bispecific molecules that are capable of localizing an immune effector cell that expresses an activating receptor to a virally infected cell, so as to thereby facilitate the killing of the virally infected cell. In a preferred embodiment, such localization is accompl...
PYR1-like SnRK2: SNF1-related protein kinase 2 TF: Transcription factor PP2C: 2C-type protein phosphatase RCAR1: Regulatory component of ABA receptor 1 ROS: Reactive oxygen species References Acevedo-Hernandez GJ, Leon P, Herrera-Estrella LR (2005) Sugar and ABA responsiveness of a ...
(DSB) repaired by homologous recombination during DNA replication, causing an SCE1. DSBs are random independent events that occur naturally during a cell’s lifespan and, therefore, are unlikely to occur at the same position in multiple single cells2. Instead, a strand state change at the ...