The cell was described as the fundamental unit of life, but also the basal element of pathological processes. In his publication—Cellularpathologie—he created a pathogenic concept that all diseases are the result of changes in normal cells [3, 49]. In the publication of Cellular Pathology (...
Cell segmentation is the process of identifying and separating individual cells within an image, which is crucial for disease diagnosis and classification. It involves using traditional segmentation methods or deep learning techniques like CNNs to improve accuracy, although the latter requires significant ...
The increasing generation of population-level single-cell atlases has the potential to link sample metadata with cellular data. Constructing such references requires integration of heterogeneous cohorts with varying metadata. Here we present single-cell population level integration (scPoli), an open-world...
CD8+T cells represent the complementary arm of the immune system that effectively controls viral replication during natural infection12and in vaccination settings13. Historically, successful vaccines such as those against smallpox and yellow fever induce strong and long-lasting CD8+T cell responses14,15...
Because stem cell therapy already has a large impact on many aspects of life, it should not be treated differently. Currently, there are several challenges concerning stem cells. First, the most important one is about fully understanding the mechanism by which stem cells function first in animal...
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Kinases are conserved during evolution. Orthologs with 'kinase domains' (so-called protein kinase-like folds; PKL) are found in all three domains of life, [1]. Interestingly, comparing the 'kinomes' from nematodes, insects, and vertebrates a surprising number of kinases are shared. In eukaryot...
· Persistent smoking is associated with second primary cancers, treatment complications, drug interactions, other tobacco-related medical conditions, diminished quality of life, and reduced survival. · Reports from the Surgeon General on both active smoking (http://www.cdc.gov/tobacco/data_statistics...
It takes several months in mice for one stem cell lineage to repopulate the entire crypt1,2. The expansion and fixation of stem cell clones presumably recur throughout life, but most fate marker methods can only record a single clonal dominance cycle. Previous work has shown that DNA ...
(b) The temporal scale represents changes to skin across the human lifespan. (c) The gender scale represents gender-specific differences between skin sites and function. (d) The ancestral origin scale, which affects skin characteristics and proclivity to disease. (e) The wound response scale, ...