Cell Theory All organisms are made up of cells The cell is the basic living unit of organization for all organisms All cells come from pre-existing cells 2005-2006 Activities of life Most everything you think of a whole organism needing to do, must be done at the cellular level… reproduct...
The increasing generation of population-level single-cell atlases has the potential to link sample metadata with cellular data. Constructing such references requires integration of heterogeneous cohorts with varying metadata. Here we present single-cell population level integration (scPoli), an open-world...
The mammalian brain contains many specialized cells that develop from a thin sheet of neuroepithelial progenitor cells. Single-cell transcriptomics revealed hundreds of molecularly diverse cell types in the nervous system, but the lineage relationships b
The depth of layer 4 was determined from where the visual stimulus (flash) evoked a strong response in the current source density (CSD)28,29(Fig.S1). The unit location along the cortical depth was adjusted relative to layer 4 (depth 0 indicates the center of layer 4). The estimated soma...
de Vries E, de Bruin-Versteeg S, Comans-Bitter WM, de Groot R, Hop WC, Boerma GJ, Lotgering FK, van Dongen JJ (2000) Longitudinal survey of lymphocyte subpopulations in the first year of life. Pediatr Res 47:528–537 ArticlePubMedGoogle Scholar ...
Because stem cell therapy already has a large impact on many aspects of life, it should not be treated differently. Currently, there are several challenges concerning stem cells. First, the most important one is about fully understanding the mechanism by which stem cells function first in animal...
In addition to the main role of S6k in the regulation of cell size [42], recent reports showed that S6k mediates many other physological processes, such as larval feeding behaviour [43], adult lifespan [44], and autophagy [45]. The progeny from the cross of Dcp-1 GF with the UAS-...
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The tumor microenvironment (TME) is comprised of non-malignant cells that interact with each other and with cancer cells, critically impacting cancer biology. The TME is complex, and understanding it requires simplifying approaches. Here we provide an ex
The development of single-cell and spatial transcriptomics methods was instrumental in the conception of the Human Cell Atlas initiative, which aims to generate an integrated map of all cells across the human body. These technology advances are bringing