Herpes simplex type-1 virus (HSV-1) infection significantly reduced the expression of MHC I on the cell surface. Recombinant interferons could enhance the cell-surface expression of MHC I but had no effect on MHC II. This enhancement was partially inhibited by HSV-1 infection. HSV-1 mutants ...
这些发现确立了Nef在HIV-1病毒感染和艾滋病发病中的核心作用,并支持开发Nef拮抗剂作为一种新的艾滋病疗法。 2024年3月19日,匹茨堡大学医学院的研究人员在 Cell 子刊 Cell Chemical Biology 上发表了题为:PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and ...
The mobility of cell surface MHC molecules and their ability to form dynamic associations may be related to the physiological status of the cell and to the... KM Wilson,IEG Morrison,PR Smith,... - 《Journal of Cell Science》 被引量: 120发表: 1996年 Veiling of optical single particle prop...
Here we demonstrate that embryonic cells in general show a defect in MHC class I assembly. Surface expression was rescued in the presence of an appropriate antigenic peptide, or by treatment with interferon. Consistent with this, HAM1 (ref. 9) messenger RNA was not constitutively expressed, but...
wound repair (Duschera et al., 2016). According to the International Society of Cellular Therapy (ISCT),Mesenchymal stem cellsadhere to a plastic surface, and they express their surface markers CD73,CD90, and CD105, and they are unable to express their hematopoietic markersCD14,...
Partitioning of cell surface class II expression and antigen presenting capacity of macrophages in an MHC-gene dosage model. Anim. Biotech. 2:123-143.Lin H.-K., Bloom S.E. & Dietert R.R. (1991). - Partitioning of cell surface class II expression and antigen presenting capacity of ...
The mass spectrometry proteomics data has been deposited to the ProteomeXchange Consortium (http://www.proteomexchange.org/) via the PRIDE56partner repository, project identifier PXD013832. Project name ‘Comprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monoc...
In addition to bacteria, archea, and viruses, fungi also comprise an integral part of the human microbiome where they influence the host’s immune system3. Innate immune cells detect diverse pathogen-associated molecular patterns (PAMPs) on the surface of fungal cells, including polysaccharides, ...
While chimeric antigen receptor (CAR)-T-cell therapy based on gene-editing technology has achieved significant success in treating hematological diseases, its efficacy in treating solid tumors remains limited [90]. Cell surface markers like selectins on ECs and corresponding T-cell receptors are essen...
To identify surface markers for cluster 2 (ISG+ DC) for downstream functional studies, we filtered the DEG list for cluster 2 and required that marker genes must (1) have a minimum avg_logFC threshold of 0.5; (2) have an adjusted p-value < 0.05; (3) be unique to cluster 2; (4)...