The cell wall of Gram-positive bacteria is a complex assemblage of glycopolymers and proteins. It consists of a thick peptidoglycan sacculus that surrounds the cytoplasmic membrane and that is decorated with te
The primary function of haematopoietic stem cells (HSCs) in mice and humans is to generate all blood cell types. The capacity of HSCs to generate blood cells must be balanced by mechanisms to maintain stemness during an entire lifespan4,9,10. In the lifetime of a mouse, HSCs divide only...
A protein structural domain that binds DNA and RNA, and that is found most commonly in transcription factors. It consists of a helix–turn–helix structure of 60 amino acids. GAR domain A Gly- and Arg-rich motif that adopts a repeated β-turn structure. It is found most commonly in prote...
Testing larger libraries or incorporating iterative chemical synthesis guided by structure–activity relationships (50) may be required to effectively identify new autophagy-inducing compounds. Even so, compounds 1 and 2 were repeatedly found to inhibit autophagy in Dendra2-LC3 cells, RFP-GFP-HeLa ...
These modalities can also lead to single-cell imaging capabilities by targeting endogenous cell contrast or by employing exogenous contrast generation techniques, including contrast agents that target specific cell structure or function. In this review, we present key developments, summarize recent ...
with Batchelor v1.8.0; this ensures data is downsampled based upon the batch with the smallest read depth. To restrict the feature space, we selected highly variable genes onlog+1transformed data by estimating a normalized dispersion measure [72] using the highly variable genes function in Scanp...
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and intra-cell population structure. cell syst. 2016;3:346–60.e4. https://doi.org/10.1016/j.cels.2016.08.011 . article cas pubmed pubmed central google scholar muraro mj, dharmadhikari g, grün d, groen n, dielen t, jansen e, et al. a single-cell ...
94-98% on the central slices with a decrease towards the edges of the cell where the structure was considerably more complex. The processing is unsupervised and each 2D Slice is processed in about 5-10 seconds running on a MacBook Pro. No systematic attempt to make the code faster was ...
Epigenetic modifying proteins can act differentially within CD8+ T cell differentiation subsets to regulate gene expression, and altering the activities of these enzymes can have profound effects on T cell differentiation and function. T cell exhaustion represents a state of arrested differentiation. Rever...