Nature Cell Biology volume 26, pages 153–167 (2024)Cite this article 28k Accesses 3 Citations 45 Altmetric Metrics details Abstract In the mammalian liver, hepatocytes exhibit diverse metabolic and functional profiles based on their location within the liver lobule. However, it is unclear whether...
The principal manifestation of development is cell differentiation—the structural and functional specialization of the cell. Differentiated cells have the same set of chromosomes as the fertilized egg cell; this is proved by the fact that after the nucleus of a differentiated cell is transplanted ...
Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of the macromolecular traffic across the nuclear pores is mediated by the
Biology and regulation of ectoplasmic specialization, an atypical adherens junction type, in the testis. Biochem. Biophys. Acta 2008, 1778, 692–708. [Google Scholar] [CrossRef] [PubMed] [Green Version] Wu, X.; Gao, S.; Wang, L.; Bu, T.; Wu, S.; Zhou, L.; Shi, J.; Wu, D...
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Definition Chapters and Articles Related Terms Recommended Publications Featured Authors Chapters and Articles You might find these chapters and articles relevant to this topic. Cell division, growth and death / Cell differentiation Yohanns Bellaiche, Monica Gotta, in Current Opinion in Cell Biology, ...
(Grant No. 31970638, 61572361, 62088101), Shanghai Shuguang Scholars Project, Shanghai Excellent Academic Leader Project, Shanghai Science and Technology Innovation Action Plan-Key Specialization in Computational Biology and Fundamental Research Funds for the Central Universities, and Shanghai Municipal ...
proposed a concept of liver endothelial zonation and functional specialization in NASH [3]. Su et al. also identified an unanticipated aspect of 3 kind of chimeric NPCs (non-parenchymal cells) including LSECs chimeric HSCs/HCs/KCs in NAFLD mouse at the single-cell level [4]. Our scRNA-seq...
The type of response induced depends on the functional specialization of the target cell. Sometimes a single hormone triggers different responses in different cells. For example, epinephrine produces activation of skeletal muscleglycogenolysis, but it stimulateslipolysisin adipocytes. ...
Heterogeneity in endothelial origin may contribute to the tissue-specific formation and specialization of vessels. Vessel- and organ-specific specialization is governed partly by cell-intrinsic developmental pathways and transcriptional programmes, which control processes such as EC differentiation, proliferation...