Regulation of gene transcription by mitogen-activated protein kinase signaling pathways. Mitogen-activated protein kinase (MAPK) signaling pathways are key mediators of eukaryotic transcriptional responses to extracellular signals. These pathwa... AJ Whitmarsh - Biochimica et Biophysica Acta (BBA) - Molecul...
Studying membrane contact sites at high spatiotemporal resolution is still challenging. Here, authors introduce a series of dynamic chemogenetic reporters to visualize these subcellular regions and study the associated calcium signals. Paloma García Casas ...
Understanding the molecular and cellular processes involved in lung epithelial regeneration may fuel the development of therapeutic approaches for lung diseases. We combine mouse models allowing diphtheria toxin-mediated damage of specific epithelial cell types and parallel GFP-labeling of functionally dividing...
Juxtacrinesignalstargetadjacent(touching)cells.Thesesignalsaretransmittedalongcellmembranesviaproteinorlipidcomponentsintegraltothemembraneandarecapableofaffectingeithertheemittingcellorcellsimmediatelyadjacent.SignalingReceptor •Acelltargetedbyaparticularchemicalsignalhasareceptorproteinthatrecognizesthesignalmolecule.•The...
A protective response of cells to infection, inflammation involves the coordinated communication among different immune cells through an intricate cascade of molecular signals. Learn more about theInflammatory Response Pathway Products Inflammatory Response Products ...
Juxtacrinesignalstargetadjacent(touching)cells.Thesesignalsaretransmittedalongcellmembranesviaproteinorlipidcomponentsintegraltothemembraneandarecapableofaffectingeithertheemittingcellorcellsimmediatelyadjacent.SignalingReceptor •Acelltargetedbyaparticularchemicalsignalhasareceptorproteinthatrecognizesthesignalmolecule.•The...
Learn more about stem cell pathways and the transcription factors Oct-4, Sox2, and Nanog are essential for maintaining the pluripotent state of stem cells.
Cell–cell communications of various cell populations within tumor microenvironment play an essential role in primary tumor growth, metastasis evolution, and immune escape. Nevertheless, comprehensive investigation of cell–cell communications in the ccR
Ultimately, single-cell data are noisy, high-dimensional, and may contain a multitude of competing, interwoven signals. In the presence of such data, Slingshot provides a robust and modular method for lineage and pseudotime inference, that allows for novel lineage discovery, meaningful incorporation ...
摘要:DddA-derived cytosine base editors(DdCBEs)and transcription activator-like effector(TALE)-linked deaminases(TALEDs)catalyze targeted base editing of mitochondrial DNA(mtDNA)in eukaryotic cells, a method useful for modeling of m...