In the era of rationally designed synthetic biology, heterologous metabolites production, and other counter-nature engineering of cellular metabolism, we took a step back and recalled that ‘Mother(-Nature) knows best’. While still aiming at synthetic, non-natural outcomes of generating an ‘over-...
In the era of rationally designed synthetic biology, heterologous metabolites production, and other counter-nature engineering of cellular metabolism, we took a step back and recalled that ‘Mother(-Nature) knows best’. While still aiming at synthetic, non-natural outcomes of generating an ‘over-...
PTC hits also caused a broader transcriptional response different from that of MOX (Supplementary Fig.6a−e; Supplementary Data5). Specifically, the three clustered PTCs caused marked repression of the electron transport chain, cellular respiration, glycolysis, and tricarboxylic acid cycle, as well a...
The data sets were merged to only include gene symbols common to both prior to calculating the fold enrichment score. A fold enrichment of 0 indicates that no genes were found in the intersection of those two sets of top genes. Full size image Ranking genes by their cell type-associated ...
The glucose created in photosynthesis is converted into other substances, including starch, for the storage of energy. This energy can be released byrespiration. What affects photosynthesis? Four factors affect photosynthesis. The faster photosynthesis occurs, the more the plant grows. ...
In the long run, the expression of TCA cycle genes is eventually repressed by the transcriptional regulation by cAMP-Crp toward steady state as will be explained later. The inhibitory effect of NADH on CS and ICDH may be expressed explicitly in the rate equation, but the problem is that the...
Anoxic respiration control system Fnr: Fumarate and nitrate reduction Ack: Acetate kinase Acs: Acetyl coenzyme A synthetase ADH: Alcohol dehydrogenase Ask: Aspartokinase CS: Citrate synthase Eno: Enolase Fbp: Fructose bisphosphatase Frd: Fumarate reductase Fum: Fumarase GAPDH: Glycerald...
It becomes more and more important to develop appropriate models for the efficient design of the cell factory for microbial biofuels and biochemical productions, since the appropriate model can predict the effect of culture environment and/or the specifi
1a). Logistic regression analysis yielded the equation log(odds) = 0.5567 × %GMP + 0.4198 × %LMPP − 32.004, which we used to systematically stratify the MDS samples into two main groups (Fig. 1a) independently of International Prognostic Scoring System ...
Aconiti Lateralis Radix Praeparata (Fuzi in Chinese) is widely used in the clinical treatment of tumors. This study aims to explore the active fractions and underlying mechanisms of Fuzi in the treatment of non-small cell lung cancer (NSCLC). Fuzi alkalo