The microenvironment of lymph node metastasized tumors (LNMT) determines tumor progression and response to therapy, but a systematic study of LNMT is lacking. Here, we generate single-cell maps of primary tumors (PTs) and paired LNMTs in 8 breast cancer patients. We demonstrate that the activati...
we sorted CD11b+cells with a particularly high purity (>96%) and viability (~95%; Supplementary Fig.1d). We did not detect differences in the tumor size between sexes at this stage of the tumor growth (Supplementary Fig.1e).
Ch 20.Plant Growth and Reproduction Ch 21.Introduction to Fungi Ch 22.Introduction to Invertebrates Ch 23.Introduction to Vertebrates Ch 24.Physiology: Circulatory, Respiratory,... Ch 25.Physiology: Nervous, Immune, Endocrine... Ch 26.Ecology & Environment ...
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to ...
The number of NK cells was relatively low, with a count of 842 cells, and the majority of these cells were derived from JEV-infected mice (Additional file9: Fig. S9A–C). In this study, NK cells were divided into three subpopulations based on their expression of Ly6a, Ncr1, and Xcl...
T cell immunity is central to contemporary cancer and autoimmune therapies, encompassing immune checkpoint blockade and adoptive T cell therapies. Their diverse characteristics can be reprogrammed by different immune challenges dependent on antigen stimu
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to ...
Easy reproduction Due to the lack of a publicly available codebase and variances in programming languages, the diversity and complexity of deep learning methods make it difficult for researchers to reproduce the results from the original papers. Another reason specifically for deep learning approaches ...
Understanding the molecular and cellular processes involved in lung epithelial regeneration may fuel the development of therapeutic approaches for lung diseases. We combine mouse models allowing diphtheria toxin-mediated damage of specific epithelial cel
Human FOXP3+ regulatory T (Treg) cells are central to immune tolerance. However, their heterogeneity and differentiation remain incompletely understood. Here we use single-cell RNA and T cell receptor sequencing to resolve Treg cells from healthy individ