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Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, resulting in a huge socio-economic impact. Kidney is a highly complex organ and the pathogenesis underlying kidney organization involves complex cell-to-cell interaction with
Cell Reports, Volume 32, Issue 12, 2020, Article 108176 Sara C. Buch-Larsen,…, Michael L. Nielsen View PDF Principles of Membrane Adaptation Revealed through Environmentally Induced Bacterial Lipidome Remodeling Cell Reports, Volume 32, Issue 12, 2020, Article 108165 Grzegorz Chwastek,…, James...
Surprisingly, we found that while more YAP was found in the nuclei of T-leukemic cells relative to activated CD8+ T cells, nuclear YAP was present in the Y357 phosphorylated form (Fig. 5a). This result prompted us to test LCK and ZAP70, two pivotal downstream molecules of TCR signaling ...
Induced pluripotent stem cells (iPSCs) offer potential to revolutionize regenerative medicine as a renewable source for islets, dopaminergic neurons, retinal cells, and cardiomyocytes. However, translation of these regenerative cell therapies requires co
In economics, a simple demand unit elasticity occurs between price (P) and product volume (V) in the form P * V = R when revenue (R) is held constant. Years to clearance number of years required to reach peak clearance. Years to peak number of years required to reach market peak ...
Persistent HPV16 infection is a major cause of the global cancer burden. The viral life cycle is dependent on the differentiation program of stratified squamous epithelium, but the landscape of keratinocyte subpopulations which support distinct phases of
Research was conducted in accordance with the principles of the Declaration of Helsinki. Competing interests Columbia University has filed patent applications based on the technology used in these studies with JY and PAS included as inventors. The remaining authors declare that they have no competing ...
To address this gap, we investigated remodeling of Drosophila eye lattice cells (LCs), which preserve cell contacts as they narrow to form the edges of a multicellular hexagonal lattice. We found that during narrowing, LC-LC contacts dynamically constrict and expand. Similar to other systems, ...