Replacement parts: The fragmentation and mystification of the body in the human embryonic stem cell debates.Developments in human embryonic stem cell technology since their derivation in November of 1998 (Thomson, et al. 1998) have opened up a new world in which a multitude of different kinds ...
replacement therapy[53–57]. However, in order to studygeneticconditions, one would need to introducegenetic mutationsto established hESCs or derive novel hESCs from pre-implantation genetic diagnosis embryos with known disease mutations (reviewed in[58]), neither of which have been attempted forFRDA...
“We may soon have the ability to re-program the cells in the human body,” says Sen, whose team is also laying the groundwork for the nation’s first Ph.D. program in regenerative medicine and engineering. “We can make a skin cell make functional blood vessels or other tissue required...
W. et al. Replacement of lost Lgr5-positive stem cells through plasticity of their enterocyte-lineage daughters. Cell Stem Cell 18, 203–213 (2016). CAS PubMed Google Scholar Roche, K. C. et al. SOX9 maintains reserve stem cells and preserves radioresistance in mouse small intestine. ...
aIn the human body, oxidation causes free radical damage. Free radicals that exist in our body grab an electron from one of our cells to become stable and in the process damage the DNA of the cell so that when it divides, the new cell carries the mutant DNA that in turn passes along ...
Parkinson’s disease (PD) is the second most common neurodegenerative disease, and no curative therapy is currently available [1]. Thus, alternative solutions are urgently needed. PD has long been considered to be among the most promising target diseases for cell replacement therapy due to the sp...
相关研究结果于2023年1月12日在线发表在Cell期刊上,论文标题为“Structures of the entire human opioid receptor family”。论文通讯作者为中国科学院受体研究重点实验室的Eric Xu博士、Youwen Zhuang博士和北卡罗来纳大学教堂山分校的Bryan L. Roth博士。
Chang, R.; Faleo, G.; Russ, H.A.; Parent, A.V.; Elledge, S.K.; Bernards, D.A.; Allen, J.L.; Villanueva, K.; Hebrok, M.; Tang, Q.; et al. Nanoporous Immunoprotective Device for Stem-Cell-Derived β-Cell Replacement Therapy.ACS Nano2017,11, 7747–7757. [Google Scholar]...
(programmed cell death). Apoptosis is believed to be necessary during normal differentiation of tissues in development and for replacement of aging cells in the adult. Abnormalities in apoptosis may play a role in cancer; as many as 90% of cancer cells have reactivated telomerase, which may ...
et al. Impact of growth hormone (GH) deficiency and GH replacement upon thymus function in adult patients. PLoS ONE 4, e5668 (2009). PubMed PubMed Central Google Scholar Fahy, G. M. et al. Reversal of epigenetic aging and immunosenescent trends in humans. Aging Cell 18, e13028 (...