源于人多能干细胞的人肝脏类器官(HLO)为此提供了一种潜在的解决方案。 今天,我们特别关注一项中国科学院上海营养与健康研究所丁秋蓉研究团队于2023年3月发表在《Cell Regeneration》的研究——《Modeling drug-induced liver injury and screening for anti-hepatofibrotic compounds using human PSC-derived organoids》,...
Cell Regeneration丨利用人诱导多能干细胞(iPSC)衍生的类器官模拟药物诱导的肝损伤并筛选抗肝纤维化候选药物 编者按 由于种间差异,依赖动物试验来预测药物的临床疗效、毒理学等,会造成难以避免的预测偏差,最终导致大量药物开发失败。因此,开发能够准确评估和预测候选药物对人肝组织毒性和疗效的体外肝脏细胞模型迫在眉睫。...
S. et al. Enhanced immune system regeneration in humans following allogeneic or autologous hemopoietic stem cell transplantation by temporary sex steroid blockade. Clin. Cancer Res. 14, 1138–1149 (2008). This is the first observation showing that pharmacological ablation of sex steroids enhances ...
2. Gurtner, G.C., Werner, S., Barrandon, Y., and Longaker, M.T. (2008).Wound repair and regeneration.Nature453, 314–321. https://doi.org/10.1038/nature07039. 3. Zomer, H.D., and Trentin, A.G. (2018). Skin wound...
From the preceding, it is clear that there is accumulating evidence that epithelial cell regeneration is largely centred in the periph eral cornea and limbus, that there is a general, centripetal movement from the periphery to the centre of the cornea and that this pattern is operative in ...
post-juvenile increase in cell number is primarily a replacement phenomenon. Height increase in mammals is limited by cessation of cell division and bonedepositionin the long bones. The long juvenile period of growth in humans is unusual, most higher animals attaining mature size soon after the en...
Fig. 12.Three types of lens regeneration.Iris-lens regeneration (Wolffian lens regeneration) can be observed in adult newts and the axolotl larvae, which could regenerate their lenses through transdifferentiation of cells at the edge of the iris. Cornea-lens regeneration can be observed in Xenopus...
Kim S, Shilagardi K, Zhang S et al (2007) A critical function for the actin cytoskeleton in targeted exocytosis of prefusion vesicles during myoblast fusion. Dev Cell 12:571–586 Article CAS PubMed Google Scholar Kodama S, Kühtreiber W, Fujimura S et al (2003) Islet regeneration during...
In modern biology, the correct identification of cell types is required for the developmental study of tissues and organs and the production of functional cells for cell therapies and disease modeling. For decades, cell types have been defined on the basis of morphological and physiological markers ...
“genomic recipe” for beta cell expansion, we surveyed 38 human insulinomas to obtain insights into therapeutic pathways for beta cell regeneration. An integrative analysis of whole-exome and RNA-sequencing data was employed to extensively characterize the genomic and molecular landscape of insulinomas...