While MSI arises due to defects in DNA mismatch repair genes (MLH1, MSH2, MSH6, and PMS2) that underlie DNA mismatches, as well as expansions and/or contractions of repetitive DNA sequences termed microsatellites [2,4] (reviewed in [9]), CIMP is characterized by extensive DNA methylation ...
that IEC-specific STAT3 knockout mice were more susceptible to DSS-induced colitis [37,38], suggesting that CST, by regulating the levels of STAT3 signalling in IECs, may limit the extent of mucosal inflammation and allow better mucosal healing and repair responses following an inflammatory insult...