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Cell-based therapeutic strategies have been proposed as an alternative for brain repair after stroke, but their clinical application has been hampered by potential adverse effects in the long term. The present study was designed to test the effect of the secretome of endothelial progenitor cells (...
Progesterone 3.7–11.1/>33.3 NS Yes regulation of immune responses, damage repair Mycophenolic acid 0.4–1.2/>100 NS Yes Plpro (papain-like protease) Aloperine 3.7–11.1/>33.3 NS Yes Spike Dictamnine NS 11.3–33.3/>100 No Syrosingopine NS 3.7–11.1/>100 No Ascomycin NS 3.7–11.1/>33.3 ...
Renal cell carcinoma (RCC) represents about 2–3% of all cancers with over 400,000 new cases per year. Sunitinib, a vascular endothelial growth factor tyrosine kinase receptor inhibitor, has been used mainly for first-line treatment of metastatic clear-cell RCC with good or intermediate prognosis...
Tumor suppressor p53 plays an integral role in DNA-damage induced apoptosis, a biological process that protects against tumor progression. Cell shape dramatically changes when cells undergo apoptosis, which is associated with actomyosin contraction; howe
Mesenchymal stem cell (MSC)-derived extracellular vesicles (exosomes) possess regeneration, cell proliferation, wound healing, and anti-senescence capabilities. The functions of exosomes can be modified by preconditioning MSCs through treatment with bio-
Few prospective cohort trials have investigted the effect of pretreatment nutritional and inflammatory status on the clinical outcome of patients with cancer and optimal performance status and assessed the interplay between nutrition, inflammation, body
All SectionsRadiation and Its Application in Oncology and Radiation ProtectionRadiation in Medical ImagingRadiation-Induced DNA Damage Signaling and RepairGeneral All Special IssuesBiomedical Applications of NanoscintillatorsFeature Papers for Radiation in 2021Feature Papers of Radiation 2022Innovative Approaches ...
Numerous studies have shown that hedgehog inhibitors (iHHs) only partially block the growth of tumor cells, especially in vivo. Leukemia often expands in a nutrient-depleted environment (bone marrow and thymus). In order to identify putative signaling pa