Methods: In order to decipher cell-intrinsic macrophage programs, we immortalized hematopoietic progenitors from YS and BM using conditional HoxB8, and carried out an in-depth functional and molecular analysis of differentiated macrophages. Results: While YS and BM macrophages demonstrate close ...
It also plays a multifaceted role regulating several cellular processes, including cell cycle, DNA damage repair, lysosome biogenesis, metabolism, autophagy and oxidative stress [63,64,65,66]. MITF can be further distinguished into five different isoforms: MITF-A, MITF-B, MITF-C, MITF-H and ...
However, in the adults it fails to repair injury significantly [17]. Developments in this field have largely been fueled by investigations into these model organisms and their regenerative abilities, and from the accumulating knowledge on small molecules/chemicals and key cell fate-regulators. The ...
in maturation states of newborn human lung cells. Specifically, newborn human lung matrix fibroblasts could be separated into those representative of younger cells (n= 393), or older cells (n= 158). Cells with each molecular profile were spatially resolved within newborn human lung tissue. ...
(NSCLC). The expression of PD-L1 by the NSCLC cells determines treatment effectiveness, but the relationship betweenPD-L1DNA methylation and expression has not been clearly described. We investigatedPD-L1DNA methylation, mRNA expression, and protein expression in NSCLC cell lines and tumor biopsies....