In this study, by using Aurora-A cDNA/shRNA or the specific inhibitor VX680, we show that Aurora-A upregulates cell proliferation, cell cycle progression, and anchorage-independent growth to enhance cell resistance to cisplatin and X-ray irradiation through dysregulation of DNA damage repair ...
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Aurora-A controls cancer cell radio- and chemore- sistance via ATM/Chk2-mediated DNA repair networks. Biochim Biophys Acta 2014;1843(5):934- 944.Sun H, Wang Y, Wang Z, et al. Aurora-A controls cancer cell radioand chemoresistance via ATM/Chk2-mediated DNA repair networks[J]. Biochim...
Aurora-A controls cancer cell radio- and chemoresistance via ATM/Chk2-mediated DNA repair net- works. Biochim Biophys Acta 2014;1843:934-44.Sun H, Wang Y, Wang Z, et al. Aurora-A controls cancer cellradio- and chemoresistance via ATM/Chk2-mediated DNA repair networks[ J ]. Biochim ...
Collectively, our findings represent a conceptual advance in understanding the mechanisms of corneal wound repair that may ultimately open new avenues for the development of novel therapeutic approaches to improve closure of corneal wounds. Keywords: cornea; wound healing; exosomes; extracellular vesicles;...