181For initial isolation, human embryonic diploid cells generally are used (Fig. 179-2), although for someHRVtypes, an especially sensitive strain55of a continuous cell line, HeLa, serves as well or better.57,181Some HRVs grow only in human organ cultures and, perhaps, some only in living...
Organism-level systems biology by next-generation genetics and whole-organ cell profilingdoi:10.1016/j.ibror.2019.07.115Hiroki UedaIBRO Reports
The combination of single-cell analysis, CRISPR/Cas9 gene editing, three-dimensional cell (3D cell) analysis and artificial intelligence (AI) enables in-depth exploration of tissue heterogeneity in atherosclerosis plaques, blood, liver, and the intestinal tract. This approach can guide early diagnosis...
He also examined many human and animal tissue samples, and he described blood cells (for the first time illustrated in his Arcana in 1695), sperm cells (he called semen “sperm animals”), skeletal muscle fibres, epithelial cells, teeth and circulatory system structures. He was the first to...
The organoids represent one of the greatest revolutions in the biomedical field in the past decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly similar to that of the tissue and organ. Using the regeneration ability of stem cells, a 3D organ-like structure...
The rapid emergence of spatial transcriptomics (ST) technologies is revolutionizing our understanding of tissue spatial architecture and biology. Although current ST methods, whether based on next-generation sequencing (seq-based approaches) or fluorescence in situ hybridization (image-based approaches), of...
Pathway Analysis is statistically linking observations on the molecular level to biological processes or pathways on the systems(i.e., organism, organ, tissue, cell) level. Traditionally, pathway analysis methods regard pathways as collections of single genes and treat all genes in a pathway as equ...
Small Molecules in Development of Therapeutic Drugs, Drug Toxicity, Experimental validation, Explanatory, Genome Biology, Genomic Expression, Hexokinase, Historical relevance, Human Immune System in Health and in Disease, Imaging-based Cancer Patient Management, Immunodiagnostics, Metabolomics, Methylation, Mol...
AliciaLopez, ...JialinZheng, inxPharm: The Comprehensive Pharmacology Reference, 2007 Probes Empty CellValueUnitsOrganismOrgan TissueCell Line/TypeReferenceComments Agent:125I-Fractalkine (2200 Ci/mmol) Kd:3.4pMHumanRecombinant receptorCHO cell lineCombadiere et al (1998) View chapterExplore book...
(ALT) that can be found in the cytoplasm of all cells and hepatocytes, respectively, are examples of DAMPs that are often used as clinical parameters for organ injury [17,18]. Although inflammatory responses are required for tissue healing, the debris may lead to excessive inflammation and ...