12月4日，省部共建非人灵长类生物医学国家重点实验室、昆明理工大学灵长类转化医学研究院谭韬、季维智团队，与美国得克萨斯州西南医学中心吴军、中国农业大学魏育蕾、中科院动物所于乐谦合作，在国际顶级期刊CELL杂志发表题为Dissecting embryonic and extra-embryonic lineage crosstalk with stem cell co-culture的文章。
Multiple lineage inference.One of the biggest challenges in lineage inference is determining the number and location of branching events. Some methods introduce simplifying assumptions or restrictions on discovery; for example, requiring the user to pre-specify the number of lineages or limiting the mod...
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Contemporary single-cell lineage-tracing (scLT) methods use expressed, heritable DNA barcodes to combine cell lineage readout with single-cell transcriptomics. However, reliance on transcriptional profiling limits adaptation to other single-cell assays. With CellTag-multi, we present an approach that ...
a, Characterization of genes along β-like specific lineage highlighted in Fig. 1b. Left pie-chart: Summary of genes in each category. Out of all the genes, 11876 genes with detectable expression level. 9117 genes show time dependent expression pattern. Right histogram: histogram showing the nu...
2021年12月22日,范德堡大学Ken S. Lau教授课题组在Cell杂志上发表名为Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps的文章。通过单细胞转录组学、基因组学和免疫...
Each pie chart represents the contribution of scRNA-seq cell types to the transcriptomic signature of each ST spot. Only cell types that contribute at least 10% to the spot signature are shown. (c) Up: multimodal intersection analysis (MIA) of scRNA-seq-identified cell types and ST-defined ...
A database of known cytokine/chemokine receptor and ligand pairs was constructed using combined information from CellTalkDB (http://tcm.zju.edu.cn/celltalkdb/), CellPhoneDB (https://www.cellphonedb.org/), CellChart (v1.1.1) (https://github.com/sqjin/CellChat), and resources from previous...
(D) The pie chart showed the distribution proportion of 2 KEGG pathways. (E) KEGG pathway analysis of these proteins Full size image The expression validation of CLEC1B in HCC To confirm whether CLEC1B expression was lower in HCC than in normal hepatocytes, we performed RT-qPCR and western...
created by Figdraw.bThe number of samples in the pan-cancer analysis of scRNA-seq and ST.cPie chart showing the proportion of ST sections that have corresponding scRNA-seq data from the same patient compared to those without such corresponding scRNA-seq data.dThe number of cells in the pan...