Evolutional symport/antiport ruleMembrane creationCell-like P systems with symport/antiport rules are computing models inspired by the conservation law, in the sense that they compute by changing the places of objects with respect to the membranes, and not by changing the objects themselves. In ...
Cell-like P systems with symport/antiport rules are inspired by the structure of a cell and the way of communicating substances through membrane channels between neighboring regions. In this work, channel states are introduced into cell-like P systems with symport/antiport rules, and we call ...
reversed upon simultaneous deletion ofSrsf1(Fig.3h). This was not due to alterations in nuclear localisation of β-catenin, a previously described function of Srsf1, as demonstrated by IHC analysis (Fig.S3v, w)31. These data suggest thatSrsf1promotes a less differentiated, stem cell-like phe...
The surrounding microenvironment limits tumour expansion, imposing a compressive stress on the tumour, but little is known how pressure propagates inside the tumour. Here we present non-destructive cell-like microsensors to locally quantify mechanical st
Two Programmed Cell Death Systems in Escherichia coli: An Apoptotic-Like Death Is Inhibited by the mazEF-Mediated Death Pathway In eukaryotes, the classical form of programmed cell death (PCD) is apoptosis, which has as its specific characteristics DNA fragmentation and membrane dep... A Erental...
Tumor evolution from a single cell into a malignant, heterogeneous tissue remains poorly understood. Here, we profile single-cell transcriptomes of genetically engineered mouse lung tumors at seven stages, from pre-neoplastic hyperplasia to adenocarcinoma. The diversity of transcriptional states increases ...
In addition, we found that SAUR51 (SAUR-like auxin-responsive protein) exhibited the most obvious change during this process, also indicative of a role in xylem and phloem cell dedifferentiation (Fig. 6c). In contrast, in TM-1, parenchyma cells/cambium region had a velocity trending toward ...
Lastly, we found no clear marker of the fibroblast-like epicardial population. However, we used UPK3B as a pan-epicardial marker and repeated scoring between fibroblast-like cluster 8 and mesothelial cluster 9 using only UPK3B+ cells (Extended Data Fig. 4 and Supplementary Table 8). We fo...
Of note, this phenomenon is often termed “fluidization”33,34, which in precise terms involves both softening and an increased viscous-like behavior31,36. To assess this hypothesis, we evaluated cytoskeletal organization in the different conditions. Cells stretched at very low or high rates (1...
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