[3]Lu YX,et al. A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing[J].Elife.2021,10:e62233. DOI: 10.7554/eLife.62233.[4]Pyo JO, et al. Overexpression of Atg5 in mice activates autophagy and extends lifespan[J]. Nat Comm...
2019年发表在Cell期刊杂志上的一篇来自哈佛医学院的关于线粒体通透性的研究,文章题目为“Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension”这篇研究发现当与线粒体通透性增加相结合时,自噬的升高对机体健康有害。作者推测,在 mTORC...
Current models for plasma cell lifespan are based on competition for limited niche space,11,12 or the proposition that lifespan is imprinted on plasma cells during the initial immune response.10 In the first model, new plasma cells may displace old plasma cells from the niche, a behavior cons...
相关研究结果发表在2024年8月6日的Cell Metabolism期刊上，论文标题为“Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function”。过去一百年来，人类的平均寿命显著增长，但多数老年人在生命的最后十年会经历健康状况的急剧下降，各种慢性...
4. Zhou, B., Kreuzer, J., Kumsta, C., Wu, L., Kamer, K.J., Cedillo, L., Zhang, Y., Li, S., Kacergis, M.C., Webster, C.M., et al. (2019). Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan ...
metabolically cooperating cells can shape the metabolic environment to extend their lifespan. 新陈代谢与衰老密切相关。代谢干预对衰老的影响已通过细胞内代谢、生长控制和信号传导得到解释。通过研究酵母中的时间顺序老化,我们揭示了一个迄今为止被忽视的代谢特性,该特性通过代谢物的交换影响老化。我们观察到年轻细胞...
参考文献Tokizane, Kyohei et al. “DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication.” Cell metabolism, S1550-4131(23)00462-X. 1 Jan. 2024, doi:10.1016/j.cmet.2023.12.011
【参考文献】1.Dang, W. et al. Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature459, 802, doi:10.1038/nature08085 (2009).2.Dou, Z. et al. Autophagy mediates degradation of nuclear lamina. Nature527, 105, doi:10.1038/nature15548 (2015).#优质作者榜# ...
在当下，越来越多的人热爱运动健身，以保持一副健康完美的身材。在这个过程中，部分健身者会服用一些膳食补充剂从而促进增肥增肌，例如α-酮戊二酸盐（AKG）。 近日，美国巴克衰老研究所的研究人员在 Cell Metabolism 杂志发表题为：Alpha-Ketoglutarate,an Endogenous Metabolite, Extends Lifespan and Compresses ...
Life-span, T-cell congenicBronsonii, RoderickIglesiast, AntonioMannt, MarthaGood, Robert A