Adult T-cell leukemia/lymphoma(ATLL) is a human T-lymphotropic virus 1 (HTLV-1)–associatedmalignancythat occurs in adults most frequently where the virus is endemic (southwestern Japan, central Africa, and the Caribbean basin).50There are 4 major presentations: acute, lymphomatous, chronic, an...
Leukemia stem cell immunophenotyping tool for diagnostic, prognosis, and therapeuticscytometryimmunophenotypeleukemialeukemic stem cellsurface markersThe existence of cancer stem cells is debatable in numerous solid tumors, yet in leukemia, there is compelling evidence of this cell population. Leukemic stem ...
Allogeneic hematopoietic stem cell transplantation for adult patients with mixed phenotype acute leukemia: results of a matched-pair analysis. Adult patients with mixed phenotype acute leukemia (MPAL) have a poor prognosis, and the therapeutic role of allogeneic stem cell transplantation (allo-SCT......
Molecular subgroups of T-cell acute lymphoblastic leukemia in adults treated according to pediatric-based GMALL protocols Article Open access 14 May 2024 Allogeneic hematopoietic stem cell transplantation overcome the poor prognosis of patients with IKZF1plus CD20–a very high-risk subtype in B-cell...
This paper describes how LSC functional assays, when combined with global transcriptome profiling, can be used to identify stem cell mRNA signatures that are linked to prognosis. CAS PubMed Google Scholar Goardon, N. et al. Coexistence of LMPP-like and GMP-like leukemia stem cells in acute ...
MATURE B-CELL ACUTE lymphoblastic leukemia (B-ALL) is a rare ALL subtype comprising only 2% to 4% of adults with ALL. The leukemic cells are characterized by L3 morphology according to the French-American-British (FAB) classification,1 with rare exceptions,2, 3, 4, 5 by expression of mon...
Cryptotanshinone suppresses key onco-proliferative and drugresistant pathways of chronic myeloid leukemia by targeting STAT5 and STAT3 phosphorylation Dong B, Liang Z, Chen Z, Li B, Zheng L, et. al. Science China Life Sciences 2018 pp: 1-11 Accumulation of 8,9-unsaturated sterols d...
Correction: CD38 in Hairy Cell Leukemia Is a Marker of Poor Prognosis and a New Target for Therapy. 2015;75(18):3902-3911.Poret N, Fu Q, Guihard S, Cheok M, Miller K, et al. (2015) CD38 in Hairy Cell Leukemia is a Marker of Poor Prognosis and a New Target for Therapy. Cancer...
Squamous cell carcinoma of the tongue occurring as a subsequent malignancy in a 12-year-old acute leukemia survivor. Int J Pediatr Otorhinolaryngol. 1993;26(1):89–94. Article CAS PubMed Google Scholar Tsukuda M, Ooishi K, Mochimatsu I, et al. Head and neck carcinomas in patients under...
Natural Killer (NK) cells were first described in mice by Rolf Kiessling, Eva Klein and Hans Wigzell in the 1970s as “naturally occurring killer lymphocytes” able to destroy murine leukemia cells [1, 2]. Since then, NK cells have been thoroughly studied and relatively well described as par...