@misc{xi_chen_teichlabscg_lib_structs_2023, title = {Teichlab/scg\_lib\_structs: {Release} 26th {Oct} 2023}, copyright = {Creative Commons Attribution 4.0 International}, shorttitle = {Teichlab/scg\_lib\_structs}, url = {https://zenodo.org/doi/10.5281/zenodo.10042390}, abstract = {...
We proceeded to integrate the data using other two models conditioned on the covariates that showed association with the first PC of the embedding space (experiment and cohort). Additionally, we trained a model with a dummy batch covariate, which was equal for all cells. In this case, scPoli...
To predict drug response at the single-cell level, we first used gf-icf normalization (https://github.com/gambalab/gficf) [24] to extract the top relevant genes from each cell. We then used these gene sets as input for Gene Set Enrichment Analysis (GSEA) [25] against each GDPS ranked...
Fig. 1: Clonal evolution ofTP53-sAML. a, Schematic study layout for TARGET-seq profiling of 17517 Lin-CD34+HSPCs from 31 donors.b–e, Representative examples of the four major patterns of clonal evolution inTP53-sAML patients: bi-allelic mutations (b), hemizygous mutations (c), parallel evo...
In this article, the benefits offered by micro-fibrous scaffold architectures fabricated by textile manufacturing techniques are discussed: How can established and novel fiber-processing techniques be exploited in order to generate templates matching the demands of the target cell niche? The problems rela...
The developmental potential of seven defined types (0–VI) of germ cell tumors (GCT) is determined by the developmental state of the precursor cells from which they originate: the 2C, naïve, or primed state. These basal states are modified by epigenet
The problem was that when scientists isolated ESCs in the lab, the embryo, which had potential for becoming a human, was destroyed (Fig. 8). Because of this, scientists, seeing a large potential in this treatment method, focused their efforts on making it possible to isolate stem cells ...
Barabote RD, Parales JV, Guo YY, Labavitch JM, Parales RE, Berry AM: Xyn10A, a thermostable endoxylanase from Acidothermus cellulolyticus 11B. Appl Environ Microb. 2010, 76 (21): 7363-7366. 10.1128/AEM.01326-10. Article CAS Google Scholar Lazo GR, Stein PA, Ludwig RA: A DNA Trans...
Code repositories, such as GitLab or GitHub90, are ideal to store and share code, scripts, notebooks and, when size permits, quantitative data matrices. When these become too large to be stored directly with the scripts that generate them, they should be made available in institutional or gen...
Abstract The molecular regulation of human hematopoietic stem cell (HSC) maintenance is therapeutically important, but limitations in experimental systems and interspecies variation have constrained our knowledge of this process. Here, we have studied a rare genetic disorder due toMECOMhaploinsufficiency, ch...