PT-112 is a novel immunogenic cell death (ICD)-inducing small molecule currently under Phase 2 clinical development, including in metastatic castration-resistant prostate cancer (mCRPC), an immunologically cold and heterogeneous disease state in need of novel therapeutic approaches. PT-112 has been sh...
Objective To develop, test, and validate the performance of ICD‐10‐CM claims‐based case definitions for identifying children with sickle cell anemia (SCA). Data Sources Medicaid administrative claims (2016) for children <18?years with potential SCA (any D57x diagnosis code) and newborn ...
ICD-10-CM chapter X: diseases of the respiratory system Acute tonsillitis Patients (n = 6, six females; median age [range], 37.0 [26–46] years) with clinical signs of acute tonsillitis were recruited, and the diagnosis was confirmed through a rapid antigen diagnostic test or throat cul...
Allergic rhinitis combines doctoral diagnosis of allergic rhinitis from Iceland and a questionnare data from UK biobank on hayfever or allergic rhinitis (Non-cancer-illness code 1387). As only 42 individuals had the ICD10 code for Atopic dermatitis (L20) in UK biobank we ran meta-anlysis with...
Abstract Extract: Six patients with I-cell disease (ICD) are studied. Multiple acid hydrolase deficiencies are demonstrated in cultured skin fibroblasts. These include βs-galactosidase (2% of normal), β-glucosaminidase (8% of normal), β-glucuronidase (7% of normal), α-ga-lactosidase (10%...
From 1958 to 1982 the ratio of malignant to benign giant cell tumors was 1.3, whereas from 1983 to 2011 the ratio inverted to 0.09, suggesting a change in the reporting or diagnosis of malignant or benign cases. Cases of giant cell tumor diagnosed from 1983 to 2011 displayed an age and ...
Other ICD-10 codes: C14, C14.0, C14.8. f Staging according to AJCC 7th edition. Men had more advanced tumors than women, with approximately 80 % having locally advanced or metastatic disease at the point of diagnosis. The mean age at diagnosis was slightly higher for patients with metastatic...
Atta IS. Efficacy of expressions of Arg-1, Hep Par-1, and CK19 in the diagnosis of the primary hepatocellular carcinoma subtypes and exclusion of the metastases. Histol Histopathol. 2021;36(9):981–93. CAS PubMed Google Scholar Shigematsu Y, Amori G, Kanda H, Takahashi Y, Takazawa Y,...
This is useful in the differential diagnosis of ICD from clinically simi- lar disorders such as Hurler's syndrome (MPS I), fucos- idosis, and generalized gangliosidosis (GM^-gangliosi- dosis type I) [7]. In cultured skin fibroblasts, no defi- ciency of any of the lysosomal hydrolases ...
ccRCC cells that suffer immunogenic cell death (ICD) or other forms of cell death in response to drugs or other stresses can release tumor-associated antigens, cytokines, and damage-associated molecular patterns (DAMPs) that promote recruitment, phagocytic activity and maturation of innate immune cel...