Innovating with Integrity Natera advances molecular diagnostics with integrity and scientific rigor, and supports integration of information provided by our tests into health care decision making. Our tests are clinically validated in over 200peer-reviewed publicationswith over 3 million patients studied. W...
Define cell-free. cell-free synonyms, cell-free pronunciation, cell-free translation, English dictionary definition of cell-free. Adj. 1. cell-free - lacking cells; "cell-free systems"; "a cell-free homogenate of the thyroid" acellular, noncellular - not
Sample preparation and analysis of cell-free DNA (cfDNA) were performed as previously described (Natera Inc, Austin, TX).14 Noninvasive prenatal testing (NIPT) results indicating a risk of ≥1/100 for a trisomy were categorized as high risk and those at <1/100 as low risk. In the cases...
Our objective was to retrospectively evaluate whether the levels of cell-free DNA (cfDNA) fetal fraction differed in the first trimester of pregnancies between controls and those who subsequently developed early- or late-onset fetal growth restriction (FGR).This was a case-control study conducted ...
differently on the accuracy of a test if it were explained to them that the test did not actually test fetal DNA, but instead was “cell freeplacentalDNA.” And, based on one of the last presentations I attended, they would have reason for that different perspective on the test’s ...
Of 86,902 prenatal genome-wide cell-free DNA (cfDNA) screening tests, 4,121 were positive for a chromosome abnormality. This study examines 490 cases screen-positive for one or more subchromosomal copy-number variants (CNV) from genome-wide cfDNA screeni
Circulating cell-free DNA (cfDNA) assays for monitoring individuals with cancer typically rely on prior identification of tumor-specific mutations. Here, we develop a tumor-independent and mutation-independent approach (DELFI-tumor fraction, DELFI-TF) us
This same cluster of patients, which we refer to herein as “ITH-high”, had comparable levels of tumor purity to the other “ITH-low” cluster, but demonstrated elevated ITH at the level of somatic DNA alterations, RNA, and TCR (combined Fisher exact test P = 0.0495). Moreover, ...
of a custom-built, clinically and commercially available ctDNA assay for this population.Methods:Pts with newly diagnosed HPV-negative HNSCC (all mucosal sites) treated at a single academic institution with pre-treatment ctDNA testing (Signatera, Natera) performed during clinical care were identified...
Current relevance of non-invasive prenatal study of cell-free fetal DNA in the mother’s blood and prospects for its application in mass screening of pregnant women in the Russian Federation