Cell-free DNA testingNon-invasive diagnosticsColorectal cancer screeningColorectal cancer (CRC) remains a significant global health challenge, with approximately 1.9 million new cases and 930,000 deaths reported in 2020. The highest incidence rates are observed in Australia/New Zealand and Europe, while...
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Cell-free DNA (cfDNA) screening for normal fetal aneuploidy has been widely adopted worldwide due to its convenience, non-invasiveness, and high positive predictive rate. We retrospectively evaluated 9327 Korean women with single pregnancies who underwent a non-invasive prenatal test (NIPT) to invest...
Clinical significance of DNA methylation mRNA levels of TET family members in colorectal cancer.Rawłuszko-Wieczorek AA,et al.J Cancer Res Clin Oncol.2015 Jan 4. --- Comparison of immunohistochemistry and DNA sequencing for the detection of IDH1 mutations in gliomas.Zou Y,et al.Neuro Oncol.2...
Cell-free DNA (cfDNA) in the circulating blood plasma of patients with cancer contains tumour-derived DNA sequences that can serve as biomarkers for guiding therapy, for the monitoring of drug resistance, and for the early detection of cancers. However, the analysis of cfDNA for clinical diagnos...
Multimodal epigenetic characterization of cell-free DNA (cfDNA) could improve the performance of blood-based early cancer detection. However, integrative profiling of cfDNA methylome and fragmentome has been technologically challenging. Here, we adapt an enzyme-mediated methylation sequencing method for com...
The analysis of cell-free DNA (cfDNA) as a sensitive biomarker for cancer diagnosis and monitoring has resulted in a need for efficient and standardized cfDNA isolation. In this study, we compared the isolation efficiency of the QIAamp circulating nucleic acid kit (QIA) with four other cfDNA ...
Analytical and Clinical Validation of Cell-Free Circulating Tumor DNA Assay for the Estimation of Tumor Mutational Burden Clin Chem 12.167 Intestinal Epithelial Responses to IL-17 in Adult Stem Cell-derived Human Intestinal Organoids J Crohns Colitis 10.020 Pancreatic stellate cells exploit Wnt/β-caten...
Colorectal cancer (CRC) consensus molecular subtypes (CMS) have different immunological, stromal cell, and clinicopathological characteristics. Single-cell characterization of CMS subtype tumor microenvironments is required to elucidate mechanisms of tum
Molecular approaches for colorectal cancer screening. Eur. J. Gastroenterol. Hepatol. 10, 213–217 (1998). CAS PubMed Google Scholar Ignatiadis, M. & Dawson, S. J. Circulating tumor cells and circulating tumor DNA for precision medicine: dream or reality? Ann. Oncol. 25, 2304–2313 (...