that once a finite number of PrE cells had been specified, any extra ICM cells would be defaulted to form EPI). Our first approach involved the direct microinjection of single individual blastomeres of mid-4-cell stage (E2.0) embryos, causing Tead4-KD in one quarter of the embryo (Supplem...
First, expression of neurogenic genes such as neuralized (neur) in the SOP, and expression of non-neurogenic genes in the surrounding epidermal cells downstream of N, specify tactile bristle precursor cells13,14,15 (Extended Data Fig. 1a). The SOP then divides asymmetrically, in a N-...
Briefly, we first aggregated data from 10 cells in the same cluster to make pseudo-cells for each cell type. Then R package WGCNA used to constructs a gene co-expression matrix and groups of closely co-expressed genes into modules. Hierarchical clustering of modules is displayed as topological...
Next, figure out your domestic and international calling and texting needs, whether or not you’ll require international roaming when traveling abroad, and how much cellular data you’ll need during any given month. Once you know what your service needs are, shopping for the right prepaid or ...
Using single-cell sequencing technology, the researchers traced the trajectories of individual cells over the first 24 hours of the life of an embryo, revealing a landscape of which genes are switched on or off, and when embryonic cells transition into new cell states and types. ...
Figure 3.Renal amyloidosis in the elderly. (A) In this case of kidney AL, there is extensive mesangial and glomerular capillary wall deposition of congophilic deposits (Congo red stain, ×200). (B) A case of kidney AL showing congophilic deposits in an interlobular artery with apple-green...
Previous studies have demonstrated that the potential to form a pedicle and first antler (antler generation) resides in the periosteum overlying the presumptive pedicle growth region; this is termed the antlerogenic periosteum (AP; Fig. S1A). Deletion of the AP prevents the development of pedicl...
Figure legendsmust be straight to the point, providing additional details which deepen the message of the figure itself. Please ensure that the reader, who may not be a direct expert in the field, can easily grasp the information provided. ...
Hypopharyngeal carcinoma is a cancer with the worst prognosis. We constructed the first single-cell transcriptome map for hypopharyngeal carcinoma and explored its underlying mechanisms. We systematically studied single-cell transcriptome data of 17,599
In the tongue, sweet, bitter or umami taste receptor cells form purinergic synapses with afferent nerve fibers to guide an animal in distinguishing tastants12. In the gut, this function seems to be performed by neuropod cells13,14. Neuropod cells were first documented when enteroendocrine cells, ...