Protein kinase CK2 is a highly conserved protein Ser/Thr protein kinase, consisting of 2 catalytic (αα, α′α′ or αα′) subunits and 2 regulatory (ββ) subunits3,4,5. Studies have revealed that overexpression of CK2 has been associated with the promotion of tumorigenesis in the lun...
There are three proliferation proteins known to indicate cell division:proliferating cell nuclear antigen(PCNA), Ki67 andminichromosome maintenance complex component 2(MCM2). All three are present during G1, S, G2, andM phasesof the cell cycle, but absent during G0. Antibodies that target each...
Receptor-interacting protein kinase 3 (RIP3K) is essential for necroptosis. Gnai2 The gene encoding GTP-binding regulatory protein Giα2 chain. It regulates proliferation and differentiation of several cell types, including satellite cells. Neuromuscular junctions (NMJs). The synapses between motor ...
The Apigenin, SAHA, and their combined treatment induced nuclear fragmentation and chromatin condensation in MDA-MB-231 cells (Fig.5). The reduction in cell division of MDA-MB-231 cells was observed after the treatment of Apigenin, SAHA, and their combinations as compared to control cells. This...
We next replaced theevebasal promoter with theAlcohol dehydrogenase (Adh)orHeatshock protein 70 (Hsp70)promoter. TheAdhand theHsp70basal promoters have been used widely to drive gene expression in both transgenicDrosophilaand S2 cells14,30. Swapping theevepromoter with theAdhpromoter caused a substant...
The expansion of protein–protein interaction databases and recent advances in RNA sequencing technologies have enabled routine analyses of intercellular signalling from gene expression measurements of bulk and single-cell data sets. In particular, ligand–receptor pairs can be used to infer intercellular ...
(PARK2gene expression product) is an ubiquitin E3 ligase that targets specific substrates for degradation. In addition, Parkin has been demonstrated to regulate mitochondrial biogenesis, bioenergetics, dynamics, transport, and degradation124.PINK1encodes a mitochondrial protein kinase that also protects ...
Inhibition of cell division is an active response to DNA damage that enables cells to maintain genome integrity. However, how DNA damage arrests the plant cell cycle is largely unknown. Here, we show that the repressor-type R1R2R3-Myb transcription facto
[52]. In addition, SLC7A11 activity is regulated in terms of protein–protein interactions, gene expression, and protein stability [56,57,58,59,60]. In addition to regulating GPX4 function, ferroptosis agonists also degrade GPX4 via autophagy or the ubiquitin–proteasome system [61,62,63]. ...
the transcript of the mitotic gene A1 (PIN1) mediates the entry of PKM2 into the nucleus [138]. When PKM2 enters the nucleus, it can also bind to Oct-4, and combine with many of the above mechanisms to affect the spindle, affecting the cell cycle by affecting cell division [139,140]...