Both cell–cell adhesion and oriented cell division play prominent roles in establishing tissue architecture, but it is unclear how they might be coordinated. Here, we demonstrate that the cell–cell adhesion protein E-cadherin functions as an instructiv
This is the basis of the cell differentiation from indifferent stem cells.Before the cell divides, there exists a period known as interphase in which the individual chromosomes are not visible because they are uncoiled into very long, narrow structures so that they are below the lim...
Targeting p53 gain-of-function activity in cancer therapy: a cautionary tale Laura D. Attardi Anthony M. Boutelle Editorial27 Dec 2023 Dying in self-defense: cell death signaling in animals and plants Ana J. Garcia-Saez EditorialOpen Access10 Aug 2023 ...
Differentiation, only selected genes are used to perform different functions in each cell S:DNA Replication (9 hours) G2:short gap beforemitosis, organelles and proteins for mitosis are made (4 hours) G0:Resting phase (nerve cells) M-phase Mitotic division of the nucleus (Prophase, Metaphase,...
In unicellular organisms, cell division is the process by which one cell gives rise to two daughter cells to ensure the propagation of the lineage. In multicellular animals, consecutive rounds of cell division generate all the cells required for growth, development, homeostasis and regeneration [1]...
The actin filaments of the cytoskeleton are known to play major roles in cell expansion, division and differentiation; however, less is known about their role in PCD [35, 36]. At the border of NPCD-EPCD, filaments changed from thin, organized structures coating the periphery of each ...
The actin filaments of the cytoskeleton are known to play major roles in cell expansion, division and differentiation; however, less is known about their role in PCD [35, 36]. At the border of NPCD-EPCD, filaments changed from thin, organized structures coating the periphery of each ...
Cell attachment, migration (velocity, direction), vesicle formation, angiogenesis, stem cell differentiation can be recorded using automated imaging platforms [21, 22]. Some of them are based on the label‐free phase holographic microscopy. In this technique, the low‐power (635 nm) red diode...
For example, asymmetric cell division is essential for the rejuvenation of at least some single-celled organisms and for the differentiation of some stem cells, where the two resulting daughter cells can differ in specific aspects linked to cell fate1,2,3,4. However, whether such diversifying ...
In mice, the incisor stem-cell population continuously self-renews and replenishes tissues that are lost due to gnawing, making this model attractive for studies of stem-cell generation, cell differentiation, homeostasis, and injury-induced regeneration. In addition, the mouse incisor represents a ...