Division of cytoplasm after nucleus. Delayed if cells have more than one nucleus (muscle) Active process that requires ATP Prophase Chromosomes become shorter and thicker by coiling themselves (condensation) This prevents tangling with other chromosomes Nuclear envelope disappears/breaks down Protein fibres...
The process of growth Growth is seldom random. Rather, it occurs according to a plan that eventually determines the size and shape of the individual. Growth may be restricted to special regions of the organism, such as the layers of cells that divide and increase in size near the tip of ...
Respiratory diseases are among the leading causes of death worldwide1. In the adult lung, epithelial cells possess a low steady-state turnover but can respond to lung injury with proliferation and differentiation to replace damaged cells2. Understanding the process of lung regeneration at the cellul...
5e, f). Taken together, these results indicate that S100P and SPP1 are two optimal biomarkers for distinguishing iCCAphl and iCCApps, which can effectively divide the iCCA patients into two subtypes with different cell origins and clinicopathological characteristics. Molecular profiles and transcription...
Dysfunctional replication can result in senescence, and senescent cells will not divide in response to growth signals. Markers of senescence can therefore be used as a complement to cell proliferation assays. An enlarged cell size, expression of pH-dependentβ-galactosidase activity, and an altered ...
所以一旦Dox诱导,Cas9开始表达,特定的gRNA便能target到evolving region的barcode的,Evolving barcode edits are encoded and inherited as cells divide,进而获得细胞的谱系发育关系。 Figure 1 macsGESTALT for high-resolution lineage tracing 3.Aggressive clones are rare and transcriptionally divergent ...
CSSCs display properties of mesenchymal stem cells, including clonal growth, multipotent differentiation, expression of stem cell-specific markers, ability to divide extensively in vitro and to generate adult keratocytes [11]. Genesis of corneal endothelium begins when periocular neural crest cells ...
This contrasts with pluripotent cells, which can generate all the cells in the body, but not extraembryonic tissues3,4. Thus, totipotent cells have greater cellular plasticity. However, the mechanisms that sustain totipotency are poorly understood. DNA replication is a fundamental process for genetic...
These data suggest that GSCs may have a role in cancer development and recurrence. There are presently no treatments targeting GSCs. Our understanding of glioblastoma heterogeneity, and the relevance of GSCs in this process, is limited. Here, using massively parallel single-cell RNA-sequencing (...
divide more quickly than the time needed for a single replication of the chromosome. Consistent with this hypothesis, we found that our cell-size mutants have the same DNA concentration during exponential phase (Figure 3B). We also showed that DNA concentration increases as cells exit stationary ...