Most mutations in human cancer are low-frequency missense mutations, whose functional status remains hard to predict. Here, we show that depending on the type of nucleotide change and the surrounding sequences, the tendency to generate each type of nucle
Supplementary Information accompanies the paper on the Cell Death Discovery website (http://www.nature.com/cddiscovery) Supplementary information Supplementary Information (DOC 27 kb) Supplementary Figures (PPT 3609 kb) Rights and permissions This work is licensed under a Creative Commons Attribution 4.0...
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This image below froma January 2020 study“Mast Cells: Fascinating but Still Elusive after 140 Years from Their Discovery,” is also a helpful pictorial demonstration of the many conditions that can arise when the normal mast cell process gets dysfunctional. ...
This study reveals the metabolic pathways involved in estrogen-mediated monocarbon, purine and polyamine synthesis in breast cancer, and the discovery that PPAT and AZIN1 were direct ERa targets for the cell survival and growth of breast cancer. It supplements the pathogenesis of breast cancer and...
Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of...
Turn to the next page of evolution with every click. Gain entropy to unlock the next chapter of the evolution of life. Uncover the twists and turns that led to the great milestones of evolution: the extinction of the dinosaurs, the discovery of fire, the Industrial Revolution, and more. Se...
Therefore, the only way to introduce a new stem-cell-based product onto the market is for competent authorities to make sure that the discovery is safe and effective for its intended human use, and that the product has successfully passed all of the clinical trial stages. 5. Challenges and ...